投射去中缝背核的视网膜节细胞对青光眼模型鼠抑郁情绪的调控作用

Glaucoma is a long-term eye disease requiring the life-long follow-up after diagnosis. During the progress of glaucoma, 15% of the patients are suffering from depressive symptoms. Although these depressive symptoms significantly impair the life quality of glaucoma patients, its mechanism is still unknown. It has been found that the dorsal raphe nucleus (DRN) projecting ganglion cells were not responsible for the image-formation, but directly participated in the regulation of depressive mood. The purpose of the present study is to investigate the temporal damages of DRN-projecting ganglion cells in experimental glaucoma mice and the relationship between the depression-like behaviors and the loss of DRN-projecting ganglion cells. The outcome of this project can help to understand the underlying mechanism of the depressive symptoms in glaucoma so that to provide theoretical evidence in improving the life quality of glaucoma patients and maintaining their existing retinal functions.

青光眼病是一类病程漫长，需终身监测的眼科疾病。在长期的病程进展中，有超过15%的青光眼患者饱受抑郁情绪的困扰。这些情绪障碍症状显著地影响了青光眼患者的生活质量和视功能的维护，然而目前关于青光眼患者情绪障碍的发病机制仍不清楚。但随着对视网膜功能认识的不断深入，研究发现，投射去中缝背核（dorsal raphe nucleus，DRN）的视网膜节细胞不参与传统视觉信号的形成，而直接参与抑郁情绪的调控。本课题拟研究投射去DRN的视网膜节细胞在青光眼模型鼠中的损伤情况以及其对青光眼模型鼠抑郁情绪的调控作用，以明确青光眼病中发生情绪障碍可能的原因，以期为改善青光眼患者的生活质量和保护患者现存的视网膜功能提供新的理论依据和治疗策略。

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