超声内镜引导下经十二指肠保胆取石术后胆囊病理生理功能研究

Gallstones is a kind of common diseases clinically with an increasing incidence in China year by year, which seriously affects people’s health and quality of life. The field of technology regarding cholecystolithotomy develops rapidly in recent years. Endoscopic ultrasound (EUS) guided transgastric cholecystolithotomy is a new technique in the past two years, which is indicated in the patients who are not candidates for surgery. Our team found that EUS guided cholecystolithotomy has the advantages of clean operation area of gallbladder postoperatively and low recurrence risk of stones in short term over the trasgastric approach. However, it remains to be evaluated in the long-term effectiveness and safety. In particular, studies about the long-term effect on the pathophysiological functions of the gallbladder have not been reported. Via the establishment of the animal model, this project presented a new study approach to investigate the risk of gallstones recurrence in patients who underwent EUS guided cholecystolithotomy, as well as changes of gallbladder function and anatomical effects of this procedure on the surrounding tissues, so as to provide objective basis and evaluation index for clinical application of this technique, and to provide theoretical basis for the prevention and treatment of its complications. This study will have a significant impact on the international strategy of minimally invasive treatment of gallstones, and also put forward the new ideas for the treatment of a variety of other gallbladder diseases at the same time. This project is expected to develop a safe, effective and minimally invasive treatment for patients with gallbladder diseases.

胆囊结石是一种临床常见病，在我国发病率逐年增加，严重影响人们的健康和生活。超声内镜（Endoscopic Ultrasound, EUS）引导下经胃保胆取石术是近两年出现的新技术，适用于高龄、 一般条件差等不宜行外科手术的患者。本课题组研究发现EUS引导下经十二指肠入路保胆取石术具有术后胆囊清洁，短期结石复发风险小等明显优于经胃入路的优点。然而，对于此术式的中远期有效性和安全性仍待观察，尤其对胆囊远期的病理生理功能影响仍未见报道。本项目通过动物实验，研究EUS引导下经十二指肠入路保胆取石术后胆囊结石复发风险，胆囊功能的改变情况和此术式对周边组织的解剖学影响，为该技术的临床应用提供客观依据和评价指标，为防治其近期和远期并发症提供理论基础。本项目的完成将对国际胆囊结石的微创治疗策略产生重大影响，同时，也将为多种胆囊疾病提出治疗新思路，有望为此类患者开发出安全的、高效的、微创的新型治疗手段。

胆囊结石是一种临床常见病，在我国发病率逐年增加，严重影响人们的健康和生活。超声内镜（Endoscopic Ultrasound,EUS）引导下经十二指肠保胆取石术是近两年出现的新技术，适用于高龄、一般条件差等不宜行外科手术的患者。课题组本项目通过动物实验，研究EUS引导下经十二指肠入路保胆取石术后胆囊结石复发风险，胆囊功能的改变情况和此术式对周边组织的解剖学影响，为该技术的临床应用提供客观依据和评价指标，为防治其近期和远期并发症提供理论基础。本课题组通过研究证实了EUS引导下经十二指肠入路保胆取石术具有术后胆囊清洁，短期结石复发风险小等明显优于经胃入路的优点，并证明此术式对胆囊术后功能无明显影响，在术后中远期仍具有很高的有效性和安全性。

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