基于介孔金属氧化物半导体材料的高效气体传感器及其疾病监测应用

The detection of characteristic gases in human breath is of great importance, which can facilitate the prompt and accurate disease screening in early stage. Nowadays, metal oxide semiconductor based gas sensors has received extensive attention for its property advantages of simple structure, convenient carrying and low cost, and have wide application prospect at the field of disease testing. However, the sensitivity and selectivity of the gas sensors cannot satisfy the requirement of disease screening by monitoring the characteristic gases in human breath, which greatly limits its application in disease detection. This project will fabricate mesoporous metal oxide semiconductors with tunable mesostructures, pore sizes and pore walls by using different kind of templates with diverse molecule weight in self-assembly process, and trying to improve the sensing performance by doping active components and regulating the morphologies. On this basis, we will systematically investigate the relationship between structural characteristics and sensing performances of materials, fabricate high performance gas sensors toward characteristic gases in human breath, and understanding the gas sensing mechanism. This lays the foundation for the early diagnose of diseases by using characteristic gases in human breath.

监测人体的特征呼出气体，从而进行快速且准确的疾病早期筛查，具有非常重要的意义。目前，基于金属氧化物半导体材料的气体传感器得到了广泛的关注，这种传感器结构简单、携带方便、造价较低，在疾病检测领域展现出了巨大的应用前景。但是，这种传感器的灵敏度和选择性还难以满足通过监测特征呼出气体来筛查人体疾病的要求，这极大的限制了其在疾病检测领域的应用。本项目拟使用不同种类和分子量的模板剂，通过自组装过程合成介观有序结构、孔径和孔壁尺寸等可调的介孔金属氧化物半导体材料，并尝试通过掺杂活性组分或调控材料的形貌等手段来提高其气体传感性能。在此基础上，系统研究材料的结构特性与气敏性能之间的关系，制备具有优秀特征呼出气体传感性能的材料，了解其气敏机理，为利用人体的特征呼出气体进行疾病的早期诊断奠定坚实的基础。

金属氧化物半导体材料是一类常用的气敏材料，也是气体传感器的核心组成部分。目前，面对种类繁多的特征气体，传感器的灵敏度和选择性还难以满足呼气检测疾病的要求，这大大制约了金属氧化物半导体材料在呼气传感诊断中的进一步应用。针对这一问题，本项目探索了全新的定向组装策略，选用新型嵌段共聚物模板剂，强化和匹配分子间作用力，构筑了系列具有有序孔道排列结构的新型介孔金属氧化物半导体材料，并有效调控了材料孔径尺寸、形貌等结构参数，在介孔骨架中均匀掺杂了活性功能基元，获得的材料对于不同种类气体具有优异的气体传感性能，有望在未来应用于疾病的呼气检测快速筛查。在本项目的支持下，以第一/通讯作者在Adv. Sci.、Adv. Funct. Mater、Nano Lett.等学术期刊发表论文26篇，入选国家优秀青年基金、上海市“曙光计划”等人才项目，获第十四届中国硅酸盐学会青年科技奖、上海市青年五四奖章、CCL优秀青年学者等奖项。

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