微波辅助合成手性多级孔金属-有机框架及强化降解抗生素特性研究

The environmental pollution resulted from antibiotics has become one of the major environmental problems in China and even the whole world,and chirality is the foundation of all life. The transformation law of chiral features of antibiotics in selective adsorption, degradation has not been studied. The project focuses on construction of new chiral adsorption material in microwave field, adsorption structure-activity relationship and degradation strengthening law. Using diatomite as carrier, and chiral acid and metal salt as monomers, chiral hierarchical porous metal-organic framework materials will be prepared by microwave hydrothermal method, and influence law of microwave hydrothermal conditions on chiral characteristic and surface potential will be investigated deeply. By structural characterization, simulation and adsorption analysis, effects of the chiral hierarchical porous metal-organic framework materials on adsorption properties(adsorption capacity, rate, selectivity, et al) of tetracycline, β-lactam antibiotics will be studied. Based on antibiotics existing degradation mechanism, stereoscopic structure change of antibiotics,degradation behavior and strengthening law in the chiral framework under microwave field will be revealed, then the theory and method of strengthening degradation antibiotics under microwave field will be established. The results will provide important theoretical basis and practical guidance for studying the relationship between microwave field and construction and transformation of the chiral structures of materials, and the results also provide a new way for effectively eliminating antibiotic residues in aquatic environment.

抗生素的环境污染已成为我国乃至全球所面临的重大环境问题之一，手性是一切生命的基础。抗生素的手性特征在选择性吸附、降解中的转变规律还未被研究。本项目以微波场作用下新型手性吸附材料构建-吸附构效关系-降解强化规律为研究主线。以硅藻土为载体，以手性酸、金属盐为单体，采用微波水热法制备手性多级孔金属-有机框架材料，深入研究并科学阐明微波水热条件对其手性特征及表面电位的影响规律；采用结构表征、模拟及吸附分析相关联的方法，研究框架材料对四环素类、β-内酰胺类典型手性抗生素吸附性能（容量、速率、选择性等）间的内在关系；基于抗生素现有降解机理，通过揭示微波场作用下抗生素在手性框架上的立体结构转变、降解行为及强化规律，建立微波场强化降解抗生素的方法和理论。结果将为研究微波场与材料手性结构构建、演变间的关系提供重要的理论依据和实践指导，并为我国高效消除水环境中抗生素残留探索一条新途径。

抗生素的环境污染已成为我国乃至全球所面临的重大环境问题之一。抗生素在选择性吸附、降解中的转变规律还未被研究。本项目采用微波水热法制备了一系列的MIL-101多孔金属-有机框架材料，研究了材料制备条件*对其结构特征及表面电位的影响规律；采用结构表征、模拟及吸附分析相关联的方法，研究了框架材料对四环素类典型手性抗生素吸附性能的影响。结果表明，本项目所制备的改性MIL-101材料对四环素类抗生素具有较快的吸附速率和较高的吸附容量。研究结果将为研究微波场与材料手性结构构建、演变间的关系提供重要的理论依据和实践指导，并为我国高效消除水环境中抗生素残留探索一条新途径。相关研究结果第一或通讯作者发表学术论文14篇，SCI7篇，EI1篇。培养硕士研究生9名。

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