Defining the molecular assembly mechanism of bacterial amyloid from single protein molecules to mature fibrils

定义细菌淀粉样蛋白从单个蛋白质分子到成熟原纤维的分子组装机制

• 批准号: 494840
• 负责人: Dee Derek R
• 金额: $ 7.29万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=494840&lang=en
• 关键词: Amyloid Fibrils; Bioconjugate Chemistry; Biofilm; Biophysics; Cryoem; Force Spectroscopy; Optical Tweezers; Protein Aggregation; Protein Folding; Single Molecule Methods

Many bacteria can form a dense matrix known as biofilm that helps them attach to surfaces and offers protection, aiding their survival. A key structural component of biofilm are amyloid fibrils, protein aggregates comprised of thousands of protein molecul

许多细菌可以形成一个称为生物膜的密集基质，该基质可帮助它们附着在表面上并提供保护，从而有助于其生存。生物膜的关键结构成分是淀粉样蛋白原纤维，由数千种蛋白质分子组成的蛋白质聚集体