Dynamic field monitoring during in vivo MRI

体内 MRI 期间的动态场监测

• 批准号: RTI-2023-00108
• 负责人: Baron, Corey
• 金额: $ 7.58万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=764580
• 关键词: Dynamic; field; monitoring; during; vivo

Magnetic resonance imaging (MRI) utilizes very strong magnetic fields to obtain images of tissue within the body. However, there are always small unwanted magnetic fields present that can cause errors in the images. Conventionally, these errors are reduced by using data sampling techniques that are less sensitive to the unwanted fields, but this strategy creates limits on how we can use the MRI. "Field probe monitoring" is a recently introduced technology that allows direct and accurate measurement of these fields. With knowledge of the fields, the errors can be completely removed, which lifts the restrictions we normally abide by to limit the errors from the fields. Accordingly, this enables advanced methods that can provide greatly improved MRI image quality and resolution. We recently acquired a field probe monitoring system for our 7 Tesla MRI, and have made numerous research contributions using it. However, we recently suffered a devastating setback to our research when the 7 Tesla MRI machine underwent a spontaneous "quench", which is a serious malfunction that may have caused permanent damage to the MRI. Luckily, the primary component of our field probe system - the "spectrometer", which collects the signals from field probes - can also be used with our 3 Tesla MRI. The set of field probes that actually detect the unwanted fields within the scanner can only work at the particular MRI field strength it was designed for, though, and we are thus requesting funding for the purchase of a set of field probes for our 3 Tesla MRI. This equipment will allow us to continue our fruitful line of research into field probe monitoring-based methods to improve MRI image quality and reliability. There are many advanced MRI approaches that have not yet been translated to clinical use because of concerns with image quality and reliability, and by solving these issues this work will enable more accurate diagnosis for patients and improved understanding of disease.

磁共振成像（MRI）利用非常强的磁场来获得体内组织的图像。但是，总是存在一些不需要的磁场，可能会导致图像中的错误。通常，通过使用对不需要领域敏感的数据采样技术来减少这些错误，但是该策略限制了我们如何使用MRI。 “现场探测监测”是一项最近引入的技术，可直接准确地测量这些磁场。有了了解字段，就可以完全删除错误，这取消了我们通常遵守的限制，以限制字段中的错误。因此，这使得可以极大地改善MRI图像质量和分辨率的高级方法。最近，我们为我们的7台特斯拉MRI购买了一个现场探测监测系统，并使用它做出了许多研究贡献。但是，当7台特斯拉MRI机器发生自发的“淬火”时，我们最近对研究遭受了毁灭性的挫折，这是一种严重的故障，可能对MRI造成了永久性损害。 幸运的是，我们现场探针系统的主要组件 - 从现场探针中收集信号的“光谱仪”也可以与我们的3个特斯拉MRI一起使用。但是，实际上检测到扫描仪内有不良场的一组现场探测器只能在其设计的特定MRI场强度下工作，因此我们要求为购买3个Tesla MRI的一组现场探测提供资金。该设备将使我们能够继续进行基于现场探针监测的方法，以提高MRI图像质量和可靠性。由于对图像质量和可靠性的担忧，有许多先进的MRI方法尚未转化为临床使用，并且通过解决这些问题，这项工作将使患者更准确地诊断并提高对疾病的了解。