Charting subject-specific tau propagation along the gradients of brain connectivity in Alzheimer's disease

绘制阿尔茨海默病中特定受试者 tau 蛋白沿着大脑连接梯度的传播图

• 批准号: 479415
• 负责人: Goubran Maged
• 金额: $ 52.67万
• 依托单位: Sunnybrook Research Institute (Toronto, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=479415&lang=en
• 关键词: Alzheimer'S Disease; Cognitive Impairment; Computational Analyses; Connectomics; Disease Phenotypes; Machine Learning; Magnetic Resonance Imaging; Positron Emission Tomography; Subtyping And Staging; Tau Spread

Alzheimer's disease (AD) is characterized by heterogeneous patient subgroups with unique progression rates and patterns, complicating diagnosis and treatment. In AD, a protein called 'tau' abnormally spread throughout the brain along brain networks, contr

阿尔茨海默病 (AD) 的特点是患者亚群异质，具有独特的进展速度和模式，使诊断和治疗变得复杂。在AD中，一种名为“tau”的蛋白质沿着大脑网络异常地遍布整个大脑，控制