X-linked Hypophosphatemic Rickets (XLH), a Primary Skeletal Dysplasia with Superimposed Rickets

X连锁低磷血症性佝偻病（XLH），一种原发性骨骼发育不良伴叠加性佝偻病

• 批准号: 478164
• 负责人: Karaplis Andrew C
• 金额: $ 55.45万
• 依托单位: Lady Davis Institute for Medical Research (Mtl)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=478164&lang=en
• 关键词: Burosumab; Chondrocytes; Fgf23; Growth Plate; Rickets; Xlh

X-linked hypophosphatemic rickets (XLH) is a genetic disorder that affects the bones, causes severe rickets, and slows growth. Arising from mutations in a protein called PHEX, it leads to high levels of a hormone called FGF23, which causes problems with p

X 连锁低磷血症性佝偻病 (XLH) 是一种影响骨骼、导致严重佝偻病并减缓生长的遗传性疾病。它由一种名为 PHEX 的蛋白质突变引起，会导致一种名为 FGF23 的激素水平升高，从而导致 p 问题