Development and Update of Quantitative Pharmacology Concepts and Computational Models for a Better Understanding of Drug Fate and Action

定量药理学概念和计算模型的发展和更新，以更好地了解药物的命运和作用

基本信息

批准号：
RGPIN-2020-05982
负责人：
Nekka, Fahima
金额：
$ 1.75万
依托单位：
Université de Montréal
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2022
资助国家：
加拿大
起止时间：
2022-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762039
关键词：
Development Update Quantitative Pharmacology Concepts

项目摘要

This research program bases on solid theoretical foundations to provide mathematical methodologies that help gaining better insights into the underlying mechanisms of the biological system, its transition between healthy and pathological conditions, and its action on/reaction with exogenous compounds. It addresses highly topical issues that became very important with the increasing role that mathematics play in the drug research area. It focuses on the development of advanced quantitative methodologies that are part of an integrative approach combining systems pharmacology with pharmacometrics (quantitative pharmacology). In fact, empirical culture, which historically prevailed in this field, is gradually fading to give more ground to these complementary or even alternative mathematical and computational tools, with the aim to rationalize and quantify drug development and use. Quantification of the complex relationship that exists between the drug, the patient biology and his drug behaviour is at the core of our interest. Whenever possible, concrete computational tools, nourished by the research components, are developed and bring an added value for the return on investment of public funds. This research program is fully dedicated to train a whole new generation of quantitative pharmacological scientists. It consists in three main lines, concerned with the development of integrative mathematical models, update of the most used pharmacokinetic metrics and the proposition of rational pharmacological strategies and minimally invasive approaches in a context of limited sampling, using physiological and pharmacokinetic modeling with mathematical analysis.

该研究计划基于固体理论基础，以提供数学方法论，从而有助于更好地了解生物系统的基本机制，其健康和病理条件之间的过渡以及其对外源化合物的作用/反应。它解决了高度主题的问题，这些问题随着数学在药物研究领域的越来越多的作用而变得非常重要。它重点是发展高级定量方法，这些方法是将系统药理学与药物计量学结合（定量药理学）相结合的综合方法的一部分。实际上，历史上在该领域盛行的经验文化正在逐渐消失，以使这些互补甚至替代性的数学和计算工具更加基础，旨在合理化和量化药物开发和使用。对药物，患者生物学和他的药物行为之间存在的复杂关系的量化是我们感兴趣的核心。只要有可能，研究组件就可以开发出滋养的具体计算工具，并为公共资金的投资回报带来额外的价值。该研究计划完全致力于培训新一代的定量药理科学家。它由三个主要线组成，涉及综合数学模型的发展，最常用的药代动力学指标的更新以及理性药理策略的命题以及在有限采样的背景下，使用生理和药代动力学建模和数学分析的生理和药代动力学建模。