Effects of ultra-low dose radiation on biological systems

超低剂量辐射对生物系统的影响

• 批准号: 517964-2017
• 负责人: Lees, SimonSJ
• 金额: $ 12.46万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760790
• 关键词: Effects; ultra; low; dose; radiation

All living organisms are continually exposed to background radiation. The sources of this radiation include cosmic and terrestrial radiation (e.g., radon). Additional exposure can be a result of the workplace or medical imaging. While high-dose exposure to ionizing radiation is known to cause harm, very little is known about the role background radiation has on cell function. For example, it is not known if the elimination of background radiation has a destabilizing effect on cells or organisms. Just as important, it is not known how the presence of background radiation prepares our cells to handle exposure to radiation that is above background levels (e.g., medical imaging). The Northern Ontario School of Medicine, Laurentian University and Bruce Power have partnered together to study the fundamental effects of ultra-low dose radiation on biological systems. This research will be performed using a state-of-the-art world class Canadian research laboratory designed to eliminate natural background radiation (SNOLAB). Fundamental research will be performed to examine 3 key areas: 1) accurately characterize background radiation levels within SNOLAB and in the surface control laboratory, 2) determine the effect of ultra-low dose radiation on cell function and the response to stress, and 3) determine the effect of ultra-low dose radiation on embryogenesis and cellular development. The scientific knowledge gained will be beneficial in understanding the cellular mechanisms impacted by environmental, occupational, and medical exposure to low dose radiation.

所有生物体都持续暴露于背景辐射下。 这种辐射的来源包括宇宙辐射和地面辐射（例如氡气）。 额外的暴露可能是由于工作场所或医学成像造成的。虽然已知高剂量暴露于电离辐射会造成伤害，但人们对背景辐射对细胞功能的作用知之甚少。 例如，尚不清楚背景辐射的消除是否会对细胞或生物体产生不稳定影响。 同样重要的是，尚不清楚背景辐射的存在如何使我们的细胞做好准备，以应对高于背景水平的辐射（例如医学成像）。北安大略医学院、劳伦森大学和 Bruce Power 合作研究超低剂量辐射对生物系统的基本影响。 这项研究将使用最先进的世界级加拿大研究实验室（SNOLAB）进行，该实验室旨在消除自然背景辐射。 将进行基础研究以检查 3 个关键领域：1）准确表征 SNOLAB 内和表面控制实验室的背景辐射水平，2）确定超低剂量辐射对细胞功能和应激反应的影响，以及 3）确定超低剂量辐射对胚胎发生和细胞发育的影响。获得的科学知识将有助于理解环境、职业和医疗暴露于低剂量辐射所影响的细胞机制。