Contributions of lower extremity musculature to hip and knee joint coordination, stability, and regional tissue mechanics

下肢肌肉组织对髋关节和膝关节协调性、稳定性和区域组织力学的贡献

• 批准号: RGPIN-2019-05340
• 负责人: Burkhart, Timothy
• 金额: $ 2.33万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=759843
• 关键词: Contributions; lower; extremity; musculature; hip

The long-term goal of this program is to develop a research platform of engineering tools and computational models of the lower extremity to build a comprehensive understanding of joint mechanics ranging from the tissue to whole joint levels. The overall vision of this work is that it will produce valid information to improve lower extremity injury reduction, treatment and rehabilitation strategies resulting in reduced health care costs, improved patient satisfaction and more comfortable ageing of the general Canadian population. This will be addressed through the following objectives: Objective 1) Quantify the individual muscle contributions to knee and hip joint stability in response to multi-planar and multi-joint tasks. The purpose this objective is to determine the contributions of the lower extremity musculature to hip and knee joint kinematics and kinetics. This research will indicate the role of each of the lower extremity muscles in initiating different types of motion and stabilizing the joints. Objective 2) Quantify regional stress and strain distributions in knee and hip joint soft tissue structures in response to active and passive loading protocols. A custom designed micro-CT compatible joint motion simulator, developed in my lab, will be adapted so that it is capable of applying active muscle forces to cadaveric specimens. Using a CT imaging based method, regional ligament material properties can be calculated. The results of this research objective will describe the effect of muscle contributions on hip and knee joint ligament stresses and strains. Objective 3 Development and validation of finite element models to measure joint contact mechanics. Image based finite element models will be developed and validated from CT scans taken in objective 2. Muscle tendons will be modelled as two-dimensional fiber reinforced membranes and non-linear spring elements while the ligaments will be modelled as non-linear springs. Following validation the contact mechanics within the joints will be quantified and compared across different loading conditions. The muscle-tendon forces from objective 1 will be input into the models to simulate active muscle loading I anticipate that the completion of this work will result in the most comprehensive mapping of regional tissue mechanical properties to date and how these are affected by different types of physiological loading and the surrounding musculature.

该项目的长期目标是开发一个下肢工程工具和计算模型的研究平台，以建立对从组织到整个关节层面的关节力学的全面理解。这项工作的总体愿景是，它将产生有效的信息，以改善下肢损伤的减少、治疗和康复策略，从而降低医疗保健成本，提高患者满意度，并使加拿大普通人口的老龄化更加舒适。这将通过以下目标来解决： 目标 1) 量化个体肌肉对膝关节和髋关节稳定性的贡献，以响应多平面和多关节任务。该目标的目的是确定下肢肌肉组织对髋关节和膝关节运动学和动力学的贡献。这项研究将表明每块下肢肌肉在启动不同类型的运动和稳定关节方面的作用。目标 2) 量化膝关节和髋关节软组织结构中响应主动和被动加载方案的区域应力和应变分布。我的实验室开发的定制设计的微型 CT 兼容关节运动模拟器将进行调整，使其能够向尸体标本施加主动肌肉力量。使用基于 CT 成像的方法，可以计算区域韧带材料特性。该研究目标的结果将描述肌肉对髋关节和膝关节韧带应力和应变的影响。目标 3 开发和验证用于测量接头接触力学的有限元模型。 基于图像的有限元模型将根据目标 2 中的 CT 扫描进行开发和验证。肌腱将被建模为二维纤维增强膜和非线性弹簧元件，而韧带将被建模为非线性弹簧。验证后，接头内的接触力学将被量化并在不同的负载条件下进行比较。来自目标 1 的肌肉肌腱力将被输入到模型中以模拟主动肌肉负荷。我预计这项工作的完成将得出迄今为止最全面的区域组织机械特性图，以及这些特性如何受到不同类型的影响。生理负荷和周围的肌肉组织。