Soft tissues in the pelvic region - novel characterization of properties and modifiers, and their influence on musculoskeletal loading

骨盆区域的软组织 - 特性和调节剂的新特征及其对肌肉骨骼负荷的影响

• 批准号: RGPIN-2020-05517
• 负责人: Laing, Andrew
• 金额: $ 2.91万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=757748
• 关键词: Soft; tissues; pelvic; region; novel

During fall-related impacts, the risk of tissue damage is directly related to the magnitude and distribution of impact loads. While the field generally recognizes the important influence of soft tissues on impact dynamics during falls on the lateral pelvis (i.e. `hip' region), there is limited information about the characteristics of these tissues, the factors that modify them, and algorithms that accurately describe their influence on impact dynamics. Accordingly, the proposed research, comprised of four complementary `Themes', will generate novel insights into the basic mechanical properties of the soft tissues in the pelvic region, their underlying modifiers, and how these soft tissues influence loading dynamics. Themes 1 and 2 will use novel ultrasound imaging techniques to investigate how individual factors (e.g. sex, age, body composition) influence the thickness and mechanical properties of pelvic soft tissues. This will be accomplished through a comprehensive application of shear wave elastography, and B-mode imaging synchronized with indentation force-deflection profiling. In Theme 3, human volunteers will be used to examine the influence of these soft tissue properties on lateral pelvis impact dynamics. Specifically, participants will undergo a series of loading scenarios (static lying to low energy falls). Impact kinetics applied to the pelvic skin surface will be measured with force plates and high-speed pressure measurement systems, and we will examine how the soft tissue properties examined in Themes 1 and 2 relate to impact dynamics. All previous outcomes will be integrated in Theme 4 through the use a validated mechanical hip impact simulator. Surrogate soft tissue materials, custom-made to match the range of properties observed in Themes 1-3, will be used to create up to 100 surrogate soft tissue coverings. These soft tissues, incorporated into the hip impact simulator, will undergo simulated sideways falls with a range of impact energies. Load sensing systems will measure impact kinetics, including the loads ultimately transmitted to the underlying femur. In summary, the proposed program of research will produce the world's most robust characterization of soft tissue properties in the pelvic region, in addition to the influence of these tissues on the loads applied to the hip region during lateral impacts. In addition to improving mathematical and mechanical models of lateral impact, this research will catalyze collaborations with industry partners to improve the design of engineering-based load attenuation devices for pressure sores and hip fractures. The trainees involved will experience an equitable, diverse, and inclusive research environment that uses multi-disciplinary approaches including experimental studies with humans, novel imaging technology, mechanical impact simulators, and mathematical modeling. These novel skill-sets will support their emergence as future leaders in academic or industry settings.

在与跌落相关的影响期间，组织损伤的风险与冲击负荷的大小和分布直接相关。尽管该领域通常认识到软组织对跌落过程中骨盆侧面影响动态的重要影响（即“髋关节”区域），但有关这些组织的特征，修改它们的因素以及算法准确描述其对影响动态的影响的算法的信息有限。因此，由四个互补的“主题”组成的拟议研究将产生对骨盆区域软组织基本机械性能的新见解，它们的基础修饰符以及这些软组织如何影响负载动力学。主题1和2将使用新颖的超声成像技术来研究单个因素（例如性别，年龄，身体组成）如何影响骨盆软组织的厚度和机械性能。这将通过全面应用剪切波弹性摄影以及与压痕力反射分析同步的B模式成像来实现。在主题3中，将使用人类志愿者来检查这些软组织特性对侧骨侧面影响动态的影响。具体而言，参与者将经历一系列的加载场景（静态撒谎至低能量下降）。应用于骨盆皮肤表面的撞击动力学将用力板和高速压力测量系统进行测量，我们将研究主题1和2中检查的软组织性能如何与影响动态有关。所有以前的结果将通过使用经过验证的机械髋关节冲击模拟器整合到主题4中。替代软组织材料（定制为符合主题1-3中观察到的特性范围）的定制材料将用于创建多达100个替代软组织覆盖物。这些软组织包含在臀部冲击模拟器中，将经历模拟的侧面，并具有一系列冲击能量。负载传感系统将测量影响动力学，包括最终传输给基础股骨的负载。总而言之，除了这些组织对在横向撞击期间施加到髋部区域的负载外，拟议的研究计划还将产生骨盆区域中软组织特性的最强特征。除了改善横向影响的数学和机械模型外，这项研究还将促进与行业合作伙伴的合作，以改善用于压疮和髋部骨折的基于工程的负载衰减设备的设计。参与的学员将体验一个公平，多样化和包容性的研究环境，该环境使用多学科方法，包括与人类的实验研究，新型成像技术，机械影响模拟器和数学建模。这些新颖的技能将支持他们作为学术或行业环境中未来领导者的出现。