Role of PARP-mediated NAD+ depletion in the establishment of Placental Dysfunction and Fetal Programming in the context of Maternal Obesity

PARP 介导的 NAD 耗竭在孕产妇肥胖背景下胎盘功能障碍和胎儿编程中的作用

• 批准号: 486237
• 负责人: Poisson Hannah E
• 金额: $ 1.27万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486237&lang=en
• 关键词: Cardiometabolism; Chronic Inflammation; Fetal Programming; Maternal Obesity; Mitochondria; Nicotinamide Adenine Dinucleotide; Parylation; Placenta; Pregnancy; Western Diet

Canadian females of reproductive age are demonstrating a pattern of increasing obesity prevalence(1), increasing the risk of adverse pregnancy outcomes such as gestational diabetes and preeclampsia(2-3). Additionally, obesity during pregnancy alters the d

加拿大育龄女性的肥胖患病率呈上升趋势(1)，从而增加了妊娠期糖尿病和先兆子痫等不良妊娠结局的风险(2-3)。此外，怀孕期间的肥胖会改变饮食习惯。