Experimental and theoretical study of hydrodynamics of solid particle transport in small scale

小尺度固体颗粒输运的流体动力学实验与理论研究

• 批准号: RGPIN-2017-05272
• 负责人: Ahmadi, Ali
• 金额: $ 1.68万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=752698
• 关键词: Experimental; theoretical; study; hydrodynamics; solid

The manipulation of solid particles in small scales has numerous applications including blood cell counting in hematology labs, fabrication of organs for implants and drug discovery, removal of bacteria from drinking water and monitoring particulate matter concentrations in air pollution. The efficiency of many of these applications strongly depends on the interaction of the particles with the surrounding fluid. The characterization of these interactions, however, becomes more challenging due to the decreased length and time scales in these miniaturized technologies.The proposed research program will focus on the theoretical and experimental aspects of the solid particle transport in rapidly changing small scale flows with direct application in the field of bio-printing. Bio-printing technologies have emerged to address the growing need for developing living tissue constructs that mimic the behaviour of the human body, and can be used for drug development or fabrication of functioning organs. As a new generation of bio-printers, inkjet printers have been utilized for controlled dispensing of living cells and biomaterials into specific patterns designed by computers. However, current inkjet bio-printers lack consistency, and face other problems including frequent nozzle clogging. The proposed program will fundamentally address the above mentioned challenges through the study of cell transport within the inkjet nozzles and microfluidic channels. In particular, a high speed imaging setup and numerical model will be developed to characterize the performance of inkjet cell printing systems. To increase the inkjet cell printing reliability, the use of viscoelastic bio-inks will be explored; the effects of rheological manipulation of bio-inks on the cell printing consistency will be studied. The fundamental knowledge of this novel research program can be applied in the development of technologies for handling solid particles in the small scale. These technologies will strengthen Canada's position as a leading country in advanced manufacturing and biotechnology fields. The HQP that will be trained in this program will be well suited to join the growing job market of these respective industrial fields.

小尺度上固体颗粒的操纵具有许多应用，包括血液学实验室中的血细胞计数，为植入物的器官制造和药物发现，从饮用水中去除细菌以及监测空气污染中的颗粒物浓度。许多这些应用的效率很大程度上取决于颗粒与周围流体的相互作用。然而，由于这些微型技术中的长度和时间尺度的减少和时间尺度，这些相互作用的表征变得更具挑战性。拟议的研究计划将重点放在固体粒子传输的理论和实验方面，并在迅速变化的小尺度流中使用直接应用。在生物印刷领域。已经出现了生物印刷技术，以满足开发模仿人体行为的生存组织构建体的需求，并可用于药物开发或功能器官的制造。作为新一代的生物发电机，喷墨打印机已被用于控制活细胞和生物材料的分配成由计算机设计的特定模式。但是，当前的喷墨生物发电机缺乏一致性，并且面临其他问题，包括频繁的喷嘴堵塞。拟议的程序将通过研究喷墨喷嘴和微流体通道内的细胞运输从根本上解决上述挑战。特别是，将开发高速成像设置和数值模型，以表征喷墨细胞打印系统的性能。为了提高喷墨细胞打印可靠性，将探讨使用粘弹性生物墨水的使用；将研究生物墨水对细胞打印一致性的流变学操纵的影响。该新型研究计划的基本知识可以应用于用于处理小规模固体颗粒的技术。这些技术将加强加拿大在高级制造和生物技术领域的领先国家的地位。将在该计划中接受培训的HQP将非常适合加入这些各自的工业领域的不断发展的就业市场。