On-demand continuous flow manufacturing of cannabidiol (CBD) and other cannabinoids

大麻二酚 (CBD) 和其他大麻素的按需连续流制造

• 批准号: 570513-2021
• 负责人: Charette, AndréAB
• 金额: $ 18.07万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748585
• 关键词: demand; continuous; flow; manufacturing; cannabidiol

The partnership between BioVectra Inc. and Prof. André B. Charette-Université de Montréal is a milestone towards an in-house Canadian manufacturing of high quality compounds in order to meet an increasing Canadian market demand. This approach will allow to mitigate Canada's heavy reliance on foreign suppliers and hence empower the Canadian economy and health care system. Specifically, the goal of this partnership is to develop an efficient synthetic route under continuous flow conditions to manufacture and supply on demand the two advanced intermediates, olivetol and p-menthadienol in order to make highly pure cannabidiol (CBD). These two precursors are very expensive and are currently supplied from China. A cost analysis has shown that if the costs of production of these two advanced intermediates are decreased, the cost of a 100% Canadian-made CBD would be favorably compete with its current price. The optimal synthetic procedure using continuous flow techniques will be develop within the Center for Continuous Flow Synthesis (CCFS), a state of the art laboratory located at Université de Montréal. The optimized process will then be effectively transfer to BioVectra's continuous flow large scale manufacturing facility for mass production and market distribution of CBD. This partnership is a turn-key solution to rapidly, safely and effectively supply the North American market with this important API. Through this partnership, trainees will gain experience in solving real world problems and well thought after pluri-disciplinary knowledge that will promote their successful entrance in the work force.

Biovectra Inc.与AndréB。Charette-UniversitédeMontréal教授之间的合作关系是朝着加拿大内部加拿大高质量化合物制造的里程碑，以满足加拿大市场日益增长的市场需求。这种方法将使加拿大对外国供应商的严重依赖，从而赋予加拿大经济和卫生保健系统。具体而言，该伙伴关系的目的是在连续流条件下开发有效的合成路线，以按需生产和供应两个高级中间体Olivetol和p-menthadienol，以制造高度纯的大麻二醇（CBD）。这两个先驱非常昂贵，目前是从中国提供的。一项成本分析表明，如果这两个高级中间体的生产成本降低，那么100％加拿大CBD的成本将与当前价格竞争。使用连续流动技术的最佳合成程序将在连续流合成中心（CCFS）中开发，这是位于蒙特利尔大学的最先进的实验室的状态。然后，优化过程将有效地转移到Biovectra的连续流量大规模制造设施中，以进行大规模生产和CBD市场分布。这种合作伙伴关系是一种旋转，安全，有效地为北美市场提供这一重要API的交钥匙解决方案。通过这种伙伴关系，学员将获得解决现实世界中问题和经过深思熟虑的经验，这将促进他们成功进入劳动力的知识。