In situ structural analysis of poliovirus during uncoating and encapsidation

脊髓灰质炎病毒脱壳和包壳过程中的原位结构分析

• 批准号: 473850
• 负责人: Wozny Michael R
• 金额: $ 9.83万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=473850&lang=en
• 关键词: Cryo-Electron Microscopy; Cryo-Focussed Ion Beam Milling; Enterovirus; In Situ Structural Determination; Integrative Cell Biology; Poliovirus Encapsidation; Poliovirus Uncoating

During a viral infection, viruses pass their genetic material from inside their viral shells into our cells to produce more viruses. Newly produced viral proteins are assembled into viral shells which must be packed with fresh viral genomes. Viral genome

在病毒感染期间，病毒将其遗传物质从病毒壳内传递到我们的细胞中，以产生更多的病毒。新产生的病毒蛋白被组装成病毒壳，其中必须装有新鲜的病毒基因组。病毒基因组