Roles of the Lysine Methyl Transferase (KMT) 2D in hepatocyte cell identity and hepatocellular carcinoma (HCC) progression

赖氨酸甲基转移酶 (KMT) 2D 在肝细胞细胞识别和肝细胞癌 (HCC) 进展中的作用

• 批准号: 472010
• 负责人: Park Kwangjin
• 金额: $ 9.83万
• 依托单位: BC Cancer, part of PHSA (Vancouver)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=472010&lang=en
• 关键词: Cancer; Cell Signaling; Epigenetics; Histone Modifications; Liver Development; Mouse; Organoids; Single Cell Transcriptomics; Transcriptional Regulation

The death rate caused by hepatocellular carcinoma (HCC), the most common liver cancer, has been globally increasing over recent decades. However, current therapeutic options are limited due to the lack of knowledge about the underlying mechanisms of HCC.

肝细胞癌（HCC）是最常见的肝癌，近几十年来，全球范围内的死亡率一直在上升。然而，由于缺乏对 HCC 潜在机制的了解，目前的治疗选择有限。