Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity

肿瘤分泌核苷可促进 RbFox1 降解以及与心肌细胞去分化相关的信号通路；

• 批准号: 467633
• 负责人: Sutendra Gopinath
• 金额: $ 83.6万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=467633&lang=en
• 关键词: Apoptosis Susceptibility; Dna Damage; Heart Failure; Mitochondria; Oncology; Paracrine Signalling; Tumor-Secreted Factors

It is well-documented that tumor cells can secrete numerous signalling factors that affect distant normal tissues. For example, tumor-secreted inflammatory factors can initiate muscle or fat tissue breakdown into protein or fatty acids, respectively, that

有充分记录的肿瘤细胞可以分泌影响远处正常组织的许多信号传导因子。例如，肿瘤分泌的炎症因子可以分别引发肌肉或脂肪组织分解成蛋白质或脂肪酸，这些因素分别为蛋白质或脂肪酸。