Defining the role of fetal reprogramming in the gut epithelium in health and disease.

定义胎儿肠道上皮重编程在健康和疾病中的作用。

• 批准号: 469443
• 负责人: Gregorieff Alex
• 金额: $ 54.62万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=469443&lang=en
• 关键词: Colorectal Cancer; Conditional Ko Mice; Fetal Gut Development; Fetal Reprogramming; Hippo Signaling; Intestinal Regeneration; Intestinal Stem Cell; Organoids; Tgf-Beta Signaling; Wnt Signaling

During embryonic development, pluripotent stem cells play a fundamental role in creating the wide variety of tissue types in our bodies. More specialised stem cells are also critical in ensuring that tissues maintain an ability to repair themselves follow

在胚胎发育过程中，多能干细胞在我们体内创建各种组织类型方面起着基本作用。更专业的干细胞对于确保组织保持修复的能力也至关重要