Development of selective and highly sensitive organic thin film transistor based bio sensors

开发基于选择性和高灵敏度有机薄膜晶体管的生物传感器

• 批准号: RGPIN-2020-04079
• 负责人: Lessard, Benoit
• 金额: $ 2.4万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=739656
• 关键词: Development; selective; highly; sensitive; organic

Wearable or implantable, sensor-laden devices can detect key physiological parameters, store data, and even deliver drugs when needed. The use of organic electronics is either essential or highly beneficial to the functioning of all these applications. Organic electronics are devices that use conductive carbon based materials instead of silicon. They are relatively inexpensive to manufacture and can easily be integrated into flexible and even biocompatible substrates. However, as an emerging technology, more research is needed to improve performance, device stability and lifetime, and to understand, as well as predict, device interaction with biological environments. Organic thin film transistors (OTFTs) are based on field-effect controlled current allowing for basic logic-gate operations. OTFT-based sensors have been used in numerous applications, such as glucose sensing, for in-situ medical diagnostics, detecting explosive materials, building artificial skin or "e-skin" for next-generation robotics/health monitoring, and as an electronic nose for detection of spoiled food. My research group has used both n-type and p-type-based OTFTs to fabricate specific DNA sensors and Cannabinoid-based sensors. The versatility inherent in organic small molecules and polymers facilitates a unique chemical response between an analyte of interest and the active material, and can subsequently translate this response into an electrical signal. We have also studied the effect of different environments on various semiconductor materials and OTFT operation, which is key to understanding the potential use of materials in sensors. The major challenge is that these sensors do not produce enough current when exposed to analytes and therefore must be characterized using expensive electrical source meters. For hand held, point of care operation using off the shelf electronic components we require significant increases in current from the resulting sensors. This program aims to improve the absolute current generated and the current differential generated from the sensors through: A) Engineering air stable and high performing silicon phthalocyanine semiconductors; B) Development of high capacitance poly(ionic liquid) block copolymer electrolyte gating medium and C) High performing devices through directional shearing and surface induced crystallization. Finally, this program will enable the design and development of a platform to evaluate highly selective disposable point of care biosensors. From on the spot detection of food decay and food born pathogens for improved food safety to the detection of narcotics for improved law enforcement: this type of sensor platform has a plethora of viable commercial applications.

可穿戴或可植入的载有传感器的设备可以检测关键的生理参数，存储数据，甚至在需要时提供药物。有机电子的使用是必不可少的，要么对所有这些应用的功能非常有益。有机电子是使用导电碳材料而不是硅的设备。它们的制造相对便宜，并且可以轻松地集成到柔性甚至生物相容性的基材中。但是，作为一项新兴技术，需要更多的研究来改善性能，设备稳定性和寿命，并了解并预测设备与生物环境的相互作用。有机薄膜晶体管（OTFTS）基于现场效应控制的电流，允许基本的逻辑栅极操作。基于OTFT的传感器已用于多种应用，例如葡萄糖传感，现场医学诊断，检测爆炸性材料，建造人造皮肤或“ E-Skin”进行下一代机器人/健康监测，以及作为可检测宠物食品的电子鼻子。我的研究小组使用了N型和基于P型的OTFTS来制造特定的DNA传感器和基于大麻素的传感器。有机小分子和聚合物中固有的多功能性促进了感兴趣分析物与活动材料之间的独特化学响应，随后可以将此响应转化为电信号。我们还研究了不同环境对各种半导体材料和OTFT操作的影响，这是了解材料在传感器中潜在使用的关键。主要的挑战是，这些传感器在暴露于分析物时不会产生足够的电流，因此必须使用昂贵的电源表进行表征。对于手持，使用货架电子组件使用的护理点操作我们需要从最终传感器中显着增加电流。该程序旨在通过以下方式改善传感器产生的绝对电流和当前的差异：a）工程空气稳定且性能高的硅邻苯胺半导体； b）开发高电容性聚（离子液体）阻止共聚物电解质门控培养基和c）通过方向剪切和表面诱导的结晶的高性能设备。最后，该计划将使平台的设计和开发能够评估高度选择性的一次性护理生物传感器。从现场检测食物衰减和食物出生的病原体以改善食品安全性，再到检测用于改进执法的麻醉品：这种类型的传感器平台具有大量可行的商业应用。