Investigating Structural and Functional Network Dysfunction in Alzheimer's Disease

研究阿尔茨海默氏病的结构和功能网络功能障碍

• 批准号: 460573
• 负责人: Attarpour Ahmadreza
• 金额: --
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-01-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=460573&lang=en
• 关键词: Alzheimer'S Disease; Artificial Intelligence; Deep Learning; Light Sheet Microscopy; Local Field Potential; Network Dysfunction; Neuronal Connectivity; Tissue Clearing

Alzheimer's disease (AD) is the most common cause of dementia. Lots of evidence suggests that AD stems from the abnormal aggregation of some proteins in the brain. This leads to a widespread neuronal circuit impairment beyond the endogenous compensation c

阿尔茨海默病（AD）是痴呆症最常见的原因。大量证据表明 AD 源于大脑中某些蛋白质的异常聚集。这导致了超出内源性补偿范围的广泛神经元回路损伤