Towards the commercialization of compressed ultrafast transmission electron microscopy (CUTEM) (Phase I)

迈向压缩超快透射电子显微镜 (CUTEM) 的商业化（第一阶段）

基本信息

批准号：
566809-2021
负责人：
Liang, Jinyang
金额：
$ 8.6万
依托单位：
Institut national de la recherche scientifique
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2021
资助国家：
加拿大
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=728726
关键词：
Towards commercialization compressed ultrafast transmission

项目摘要

Transmission electron microscopy (TEM) is indispensable to numerous applications. Its global market size, valued at US$ 556-993 million in 2020, has expanded at an average growth rate of 9.4% in the past decade. However, existing techniques do not have sufficient imaging speeds and sequence depths to follow many irreversible materials transformations or biological processes. To overcome these limitations, we recently invented compressed ultrafast transmission electron microscopy (CUTEM). Built upon a commercially available dynamic TEM system, CUTEM will add a spatial encoding mask at the selected area aperture plane and will apply a high-voltage ramp to the pair of sweep electrodes. With these economical and simple modifications, CUTEM will enhance the temporal resolution by 1000× and the sequence depth by 100× compared with the state-of-the-art movie-mode dynamic TEM. This unprecedented imaging capability allows CUTEM to open new avenues for studying previously inaccessible physics and chemistry in materials and biology. A market study funded by NSERC and INRS has demonstrated a great interest from both TEM manufacturers and users.This NSERC I2I-Phase I project aims to further develop the CUTEM technique toward a commercial product. In total, four Aims are proposed to integrate a spatial encoding mask and a sweep pulse generator into an existing TEM machine, to improve image reconstruction speed in CUTEM, and to demonstrate single-shot nanometer-picosecond imaging using the CUTEM prototype. The established theoretical framework, mature technical foundation, and straightforward engineering procedure endow the low technical risks of this project. In turn, these merits will ensure the on-time execution and fast progress of this project and will speed up future technology transfer and device commercialization.

电子显微镜（TEM）对于众多应用是必不可少的。过程。我们最近的压缩超快透射电子显微镜（cutem）将在所选的孔径平面上添加空间编码掩模，并将其带入扫描式电极。与艺术模式动态TEM相比，1000×的分辨率和序列深度为100×。旨在将Custem技术开发到商业上，提出了一个空间编码面膜，并将扫描脉冲发生器和扫式脉冲机器插入Exsting TEM机器Cucem，并使用Custem Cal基础演示了单次纳米 - 固定图像成像。该项目的技术风险较低。