A universal palladium precatalyst for efficient chemical synthesis of molecules and materials

用于高效化学合成分子和材料的通用钯预催化剂

基本信息

批准号：
561560-2021
负责人：
Leitch, David
金额：
$ 9.11万
依托单位：
University of Victoria
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2021
资助国家：
加拿大
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=724260
关键词：
universal palladium precatalyst efficient chemical

项目摘要

Catalysis is an enabling technology in chemical synthesis, providing the means to efficiently prepare new molecules and materials with applications ranging from solar energy harvesting to human health. Palladium-catalyzed cross-coupling is among the most powerful and widely used catalytic methods, particularly in industrial R&D to create new pharmaceuticals, agrochemicals, and organic materials. A significant challenge in applying palladium catalysis to synthesize complex molecular targets is identifying the appropriate combination of palladium source and supporting additives; industrial research groups will literally perform thousands of experiments to tackle this problem. A second major challenge is to achieve high chemical yield of the desired product on large scale while minimizing the cost of goods. For palladium catalyzed processes, this is often a delicate balance between maximizing efficiency and minimizing the catalyst amount.Our research group recently reported a robust and active family of palladium catalysts for achieving the formation of carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. This set of catalysts was designed specifically to enable and accelerate high-throughput screening for reaction discovery, and also to be user-friendly during scale-up and process optimization. This proposal seeks to bridge the divide between our fundamental, laboratory-scale insights to turn this discovery into a practical and commercialized solution for the synthesis and manufacture of new molecules and materials. Ultimately, this will help drive down the cost of medicines and green energy devices by reducing the cost of goods/manufacture.

催化是化学合成中的一项使能技术，提供了有效制备新分子和材料的方法，其应用范围从太阳能收集到人类健康。钯催化交叉偶联是最强大且应用最广泛的催化方法之一，特别是在创造新药物、农用化学品和有机材料的工业研发中。应用钯催化合成复杂分子靶标的一个重大挑战是确定钯源和辅助添加剂的适当组合；工业研究小组实际上将进行数千次实验来解决这个问题。第二个主要挑战是大规模实现所需产品的高化学产率，同时最大限度地降低商品成本。对于钯催化过程来说，这通常是最大化效率和最小化催化剂用量之间的微妙平衡。我们的研究小组最近报道了一个强大而活跃的钯催化剂系列，用于实现碳-碳、碳-氮和碳-氧的形成债券。这套催化剂专门设计用于实现和加速反应发现的高通量筛选，并且在放大和工艺优化过程中也易于用户使用。该提案旨在弥合我们实验室规模的基本见解之间的分歧，将这一发现转化为合成和制造新分子和材料的实用和商业化解决方案。最终，这将通过降低商品/制造成本来帮助降低药品和绿色能源设备的成本。