A novel air microfluidics technology - enabling active compression apparels for treating lymphedema, edema and muscle recovery for strenuous work and exercise
一种新颖的空气微流体技术——使主动压缩服装能够治疗淋巴水肿、水肿和剧烈工作和运动时的肌肉恢复
基本信息
- 批准号:560618-2021
- 负责人:
- 金额:$ 9.11万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Idea to Innovation
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Breast cancer related lymphedema. dependent edema, a secondary condition in individuals with spinal cord injury, and muscle injuries due to strenuous work/heavy exercise affect millions of people every year by diminishing the quality of life. Medical treatments for these problems are expensive often involving manual massaging the affected limb to help reduce tissue swelling and improve blood circulation followed by bandaging further reducing swelling or lifting the muscle. It is in high demand to develop affordable at-home compression therapy such as wearable systems with intermittent pneumatic compression mimicking the manual massaging. The global compression therapy market was valued at USD 3.1 billion in 2019 and USD 4.2 billion by 2025. The state-of-the-art technologies present trade-offs between performance, affordability and portability due to the need for the same number of electromechanical valves as the air bladders for compression.This research team has developed a novel air microfluidics powered technology which is capable of addressing the trade-off dilemma. The core technology is a microfluidic chip with a network of micro- and mini-channels enabling sequential inflation of an array of air bladder actuators which can be integrated into apparels to actively pressurize the affected limb. Feedback from our external partners including Haley Rehab, Praxis Spinal Cord Institute, Myant Inc. and the Armoury Sports Medicine suggest the need for individual control of the air bladders with a pressure-holding feature, which will be one of the key objectives for the proposed project together with other improvements such as optimizing the chip for slow and fast compression, increasing the system durability and streamlining production to reduce cost. Preliminary testing of these proposed improvements in promising applications (treatment/management of lymphedema and musculoskeletal conditions) will be performed in collaboration with our partners/potential customers. The results of the planned beta trials and application testing will help establish target market vertical(s), timing of a possible startup company's creation, and a go-to-market strategy.
乳腺癌相关淋巴水肿。依赖性水肿是脊髓损伤患者的继发性疾病,而剧烈工作/剧烈运动导致的肌肉损伤每年都会影响数百万人,降低生活质量。这些问题的医疗治疗费用昂贵,通常需要手动按摩受影响的肢体,以帮助减少组织肿胀并改善血液循环,然后包扎进一步减少肿胀或提升肌肉。人们迫切需要开发负担得起的家用压缩疗法,例如具有模仿手动按摩的间歇性气动压缩的可穿戴系统。 2019 年全球压力治疗市场价值为 31 亿美元,到 2025 年将达到 42 亿美元。由于需要相同数量的机电阀门,最先进的技术需要在性能、经济性和便携性之间进行权衡作为用于压缩的气囊。该研究团队开发了一种新颖的空气微流体驱动技术,能够解决权衡困境。核心技术是具有微通道网络的微流体芯片,能够对一系列气囊执行器进行顺序充气,这些执行器可以集成到服装中,以主动为受影响的肢体加压。 Haley Rehab、Praxis Spinal Cord Institute、Myant Inc. 和 Armory Sports Medicine 等外部合作伙伴的反馈表明,需要对具有压力保持功能的气囊进行单独控制,这将是拟议项目的关键目标之一项目与其他改进一起进行,例如优化芯片以进行慢速和快速压缩、提高系统耐用性以及简化生产以降低成本。我们将与我们的合作伙伴/潜在客户合作,对这些在有前景的应用(淋巴水肿和肌肉骨骼疾病的治疗/管理)中提出的改进进行初步测试。计划的 Beta 试验和应用程序测试的结果将有助于确定目标市场垂直领域、可能的初创公司创建的时机以及进入市场的策略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ren, Carolyn其他文献
Passive droplet trafficking at microfluidic junctions under geometric and flow asymmetries
- DOI:
10.1039/c1lc20628a - 发表时间:
2011-01-01 - 期刊:
- 影响因子:6.1
- 作者:
Glawdel, Tomasz;Elbuken, Caglar;Ren, Carolyn - 通讯作者:
Ren, Carolyn
Critical review on where CRISPR meets molecular diagnostics
- DOI:
10.1088/2516-1091/abbf5e - 发表时间:
2021-01-01 - 期刊:
- 影响因子:0
- 作者:
Lau, Anson;Ren, Carolyn;Lee, Luke P. - 通讯作者:
Lee, Luke P.
Photobleaching absorbed Rhodamine B to improve temperature measurements in PDMS microchannels
- DOI:
10.1039/b805172k - 发表时间:
2009-01-01 - 期刊:
- 影响因子:6.1
- 作者:
Glawdel, Tomasz;Almutairi, Zeyad;Ren, Carolyn - 通讯作者:
Ren, Carolyn
Real-time lead detection device based on nanomaterials modified microwave-microfluidic sensor
- DOI:
10.1016/j.sna.2023.114652 - 发表时间:
2023-09-19 - 期刊:
- 影响因子:4.6
- 作者:
Cui, Weijia;Abbasi, Zahra;Ren, Carolyn - 通讯作者:
Ren, Carolyn
Ren, Carolyn的其他文献
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{{ truncateString('Ren, Carolyn', 18)}}的其他基金
Research Program on Developing Modulated Droplet Microfluidic Systems Towards Robust Nanomaterial Synthesis
开发调制液滴微流体系统以实现稳健纳米材料合成的研究计划
- 批准号:
RGPIN-2018-04151 - 财政年份:2022
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
Research Program on Developing Modulated Droplet Microfluidic Systems Towards Robust Nanomaterial Synthesis
开发调制液滴微流体系统以实现稳健纳米材料合成的研究计划
- 批准号:
RGPIN-2018-04151 - 财政年份:2021
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
Research Program on Developing Modulated Droplet Microfluidic Systems Towards Robust Nanomaterial Synthesis
开发调制液滴微流体系统以实现稳健纳米材料合成的研究计划
- 批准号:
RGPIN-2018-04151 - 财政年份:2020
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
Development of a droplet based microfluidic system for protein separation and fractionation
开发用于蛋白质分离和分级的基于液滴的微流体系统
- 批准号:
520804-2017 - 财政年份:2020
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative Research and Development Grants
Research Program on Developing Modulated Droplet Microfluidic Systems Towards Robust Nanomaterial Synthesis
开发调制液滴微流体系统以实现稳健纳米材料合成的研究计划
- 批准号:
RGPIN-2018-04151 - 财政年份:2019
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
Development of a droplet based microfluidic system for protein separation and fractionation
开发用于蛋白质分离和分级的基于液滴的微流体系统
- 批准号:
520804-2017 - 财政年份:2019
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative Research and Development Grants
Droplet Microfluidics and Lab-on-a-Chip Technology
液滴微流控和芯片实验室技术
- 批准号:
1000229977-2013 - 财政年份:2019
- 资助金额:
$ 9.11万 - 项目类别:
Canada Research Chairs
Development of a co-culture microfluidic device that mimics vascularized tissues
开发模拟血管组织的共培养微流体装置
- 批准号:
533713-2018 - 财政年份:2018
- 资助金额:
$ 9.11万 - 项目类别:
Engage Grants Program
Development of a droplet based microfluidic system for protein separation and fractionation
开发用于蛋白质分离和分级的基于液滴的微流体系统
- 批准号:
520804-2017 - 财政年份:2018
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative Research and Development Grants
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