Development of a novel antimicrobial (AM) sprayable clear coating

开发新型抗菌 (AM) 喷涂透明涂层

• 批准号: 561220-2020
• 负责人: Kumar, Ayush
• 金额: $ 1.54万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=723609
• 关键词: Development; novel; antimicrobial; AM; sprayable

Antibiotic resistance is a global problem that threatens not only our ability to treat infections caused by bacteria, but also our economy. As we steadily exhaust effective antibiotics, preventing the spread of antibiotic resistant bacteria in environments is critical to continue our ability to use existing antibiotics. Polyamyna Nanotech Inc., a Canadian company, has developed a novel antimicrobial (AM) nanotechnology (patent pending) that has shown superior antimicrobial property against multiple antibiotic resistant bacteria. Currently used antimicrobials suffer from selecting for resistant bacteria. We will evaluate antimicrobial compounds being developed by Polyamyna Nanotech Inc. for their ability to select resistant bacteria, uncover the underlying resistance mechanism(s) and optimize the technology accordingly. This work will therefore result in the development of an antimicrobial spray that will prevent the spread of antibiotic resistant bacteria and will not select for resistant bacteria.

抗生素耐药性是一个全球问题，不仅威胁着我们治疗细菌引起的感染的能力，而且威胁着我们的经济。随着我们稳步耗尽有效的抗生素，防止抗生素耐药细菌在环境中的传播对于继续使用现有抗生素的能力至关重要。加拿大公司Polyamyna Nanotech Inc.开发了一种新型的抗菌（AM）纳米技术（专利待处理），该抗生素具有针对多种抗生素耐药细菌的优质抗菌特性。目前使用的抗菌药物因选择耐药性细菌而受苦。我们将评估Polyamyna Nanotech Inc.开发的抗菌化合物，以选择抗性细菌，揭示潜在的抗性机制并相应地优化技术。因此，这项工作将导致抗菌喷雾剂的发展，该喷雾剂可以防止抗生素耐药细菌的扩散，并且不会选择抗性细菌。