Upgrading high-resolution mass spectrometry system for advancing research in emerging environmental pollutants

升级高分辨率质谱系统以推进新兴环境污染物的研究

• 批准号: RTI-2021-00613
• 负责人: Liu, Jinxia
• 金额: $ 10.93万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718857
• 关键词: Upgrading; resolution; mass; spectrometry; system

We are requesting two pieces of peripheral instruments to upgrade a high-resolution mass spectrometry (HRMS) system. The requested PFAS-free ultrahigh performance liquid chromatography (UHPLC) will establish the UHPLC-HRMS configuration, while the requested Direct Analysis in Real-Time (DART) ion source with gradient heating functionality will create the DART-HRMS configuration. The upgraded HRMS system will support multiple research programs and projects which investigate: (i) the environmental fate, transport, effect, and remediation of per- and poly-fluoroalkyl substances (PFASs) and (ii) the environmental fate of microplastics in aquatic and urban environments. The instruments will solve the long-standing issues of high PFAS background, the significant backlog of sample analysis, and the lack of opportunity for HQP training. The complementary use of the two configurations will enable us to efficiently deal with various sample types and extract rich chemical information that otherwise is not possible. The first configuration will enable the sensitive, reliable and comprehensive characterization of PFAS-contaminated samples for tracking fluorine in novel biochemical reactions that break C-F bonds, devising remediation strategies to protect drinking water supplies and identifying PFAS in food and consumer products. The second configuration will enable quick screening of samples with little pre-treatment and the development of new characterization methods for bulk monitoring of PFAS and plastic pollution with high sensitivity and accuracy. The instruments requested will be used in 14 current interdisciplinary projects (> $ 6 million) of global reach, including 5 NSERC Discovery Grants. At least 14 collaborating organizations from the public and private sectors in Canada, the US and UK will also benefit from the instruments. The equipment will be used to immediately train 36 HQP in the next 3 years at several campuses of diverse student populations across three provinces. The state-of-the-art upgraded system will substantially enhance HQP training and quality of research to sustain the competitiveness of the future Canadian workforce in the fields of environmental and chemical engineering, applied microbiology, and nanomaterials.

我们需要两台外围仪器来升级高分辨率质谱 (HRMS) 系统。所要求的不含 PFAS 的超高效液相色谱 (UHPLC) 将建立 UHPLC-HRMS 配置，而所要求的具有梯度加热功能的实时直接分析 (DART) 离子源将创建 DART-HRMS 配置。升级后的 HRMS 系统将支持多项研究计划和项目，这些研究计划和项目调查：(i) 全氟烷基物质和多氟烷基物质 (PFAS) 的环境归趋、迁移、影响和修复，以及 (ii) 水生和生物中微塑料的环境归趋。城市环境。该仪器将解决长期存在的高PFAS背景、样品分析大量积压以及缺乏HQP培训机会的问题。两种配置的互补使用将使我们能够有效地处理各种样品类型并提取丰富的化学信息，否则这是不可能的。第一种配置将能够对 PFAS 污染的样品进行灵敏、可靠和全面的表征，以追踪破坏 C-F 键的新型生化反应中的氟，制定保护饮用水供应的修复策略，并识别食品和消费品中的 PFAS。第二种配置将能够快速筛选样品，只需很少的预处理，并开发新的表征方法，以高灵敏度和准确性批量监测 PFAS 和塑料污染。所请求的工具将用于当前全球范围内的 14 个跨学科项目（> 600 万美元），其中包括 5 个 NSERC 发现补助金。加拿大、美国和英国至少 14 个公共和私营部门的合作组织也将从这些工具中受益。这些设备将用于在未来 3 年内立即在三个省的多个学生群体不同的校园培训 36 名 HQP。最先进的升级系统将大大提高总部的培训和研究质量，以维持未来加拿大劳动力在环境和化学工程、应用微生物学和纳米材料领域的竞争力。