Investigating solutions for three major production limiting infectious diseases of dairy cattle: Mastitis, Digital Dermatitis and Johne's disease

奶牛乳腺炎、指趾皮炎、约内病三大限产传染病解决方案研究

• 批准号: 536202-2018
• 负责人: DeBuck, Jeroen
• 金额: $ 19.5万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=720107
• 关键词: Investigating; solutions; three; major; production

Infectious diseases in cattle pose threats to food safety, the livelihood of farmers, national economy, and the rural environment and communities. Reliance on treatment with antimicrobials is unlikely to be sustainable; therefore better control and prevention of infectious disease in dairy cattle is paramount. The bovine bacterial diseses, Mastitis, Digital Dermatitis and Johne's diseases have significant impacts on dairy cattle farm productivity. Through our research we will increase the understanding and improve the control of these infectious diseases and reduce the limiting effects they have on the productivity of the Canadian dairy industry. Specific projects are focused on exploring novel ways to prevent, diagnose, and eliminate these production-limiting infections from the dairy industry. The proposed research is founded on molecular microbiology, bacterial pathogenesis, disease diagnostics, pathogenomics and vaccinology. The combined program will not only generate new knowledge, but also produce several tangible end products or control strategies, including: an efficacious vaccine for Johne's disease, a probiotic against mastitis pathogens, and a pen-side diagnostic device (biosensor) to detect mastitis. We will apply a novel genetic tool to identify the niches and reservoirs of bovine Treponema spp., believed to play an important role in Digital Dermatitis lesion initiation and progression. Proposed projects will also elucidate what makes Staphylococcus chromogenes, one of the most frequently isolated organisms from subclinical mastitis, so successful as a pathogen and identify novel means to control it by elucidating bacterial targets. We will also develop and refine animal models for the above-mentioned diseases, providing a basis for innovations in prevention and control. In summary, we are proposing an original and basic research-based program to find novel ways to address important diseases plaguing the dairy industry. Projected solutions will make the dairy sector more competitive and profitable, reduce risks associated with antimicrobial resistance, improve animal welfare, and extend the social license for the dairy industry.

牛的传染病对食品安全，农民，国民经济以及农村环境和社区的生计构成威胁。依靠抗菌药物治疗的不可能是可持续的。因此，在奶牛中更好地控制和预防传染病至关重要。牛细菌疾病，乳腺炎，数字皮炎和约翰·疾病对奶牛场的生产力产生了重大影响。通过我们的研究，我们将提高对这些传染病的理解并改善对这些传染病的控制，并降低它们对加拿大乳制品行业生产率的局限性影响。特定项目的重点是探索新颖的方法来预防，诊断和消除乳制品行业的这些限制生产感染。拟议的研究建立在分子微生物学，细菌发病机理，疾病诊断，病原体学和疫苗科学上。合并后的程序不仅将产生新知识，还会产生几种有形的最终产品或控制策略，包括：Johne病的有效疫苗，针对乳腺炎病原体的益生菌和笔侧诊断装置（BioSensor）检测乳腺炎。我们将应用一种新颖的遗传工具来识别牛treponema spp。的壁ni和储层，据信在数字皮肤炎病变的启动和进展中起着重要作用。拟议的项目还将阐明是什么使葡萄球菌发色原，这是亚临床乳腺炎中最常见的生物之一，因此作为病原体而成功，并通过阐明细菌靶标来识别新的手段来控制它。我们还将开发和完善上述疾病的动物模型，为预防和控制的创新提供基础。总而言之，我们正在提出一项基于基础研究的原始计划，以寻找解决困扰乳制品行业的重要疾病的新颖方法。预计的解决方案将使乳业部门更具竞争力和有利可图，降低与抗菌素抵抗相关的风险，改善动物福利，并扩大乳制品行业的社会许可。