Role of the GPR3-SIK2 Pathway in Human Beta Cell Proliferation

GPR3-SIK2 通路在人 β 细胞增殖中的作用

• 批准号: 456702
• 负责人: Screaton Robert A
• 金额: $ 7.29万
• 依托单位: Sunnybrook Research Institute (Toronto, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=456702&lang=en
• 关键词: Cell Cycle; Diabetes; Functional Genomics; Gpcrs; Islets; Metabolism; Proliferation; Regeneration; Rnai

Our vision is to establish a complete understanding of the biology of human beta cells, the cells that make and secrete insulin after a meal. The inability to produce enough insulin results in diabetes mellitus (DM), and affects over 13M Canadians. While

我们的愿景是建立对人类 β 细胞生物学的完整理解， 餐后产生和分泌胰岛素的细胞。无法产生足够的胰岛素 导致糖尿病 (DM)，并影响超过 1300 万加拿大人。尽管