New Directions in Supramolecular and Coordination Chemistry

超分子与配位化学的新方向

• 批准号: RGPIN-2017-04899
• 负责人: MacLachlan, Mark
• 金额: $ 9.03万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=710882
• 关键词: New; Directions; Supramolecular; Coordination; Chemistry

Supramolecular chemistry, the subject of the 1987 Nobel Prize in Chemistry (and the basis of the 2016 Nobel Prize in Chemistry), is a flourishing field that exploits weak intermolecular interactions to create complex structures from simpler building blocks. This is Nature's way: building complexity from the bottom up. Using supramolecular approaches, chemists are building molecular knots, transistors, and sensors, to name only a few of the exciting developments. In our research program, we use supramolecular templating to construct complex materials. For example, using cellulose nanocrystals (CNCs) as templates, we have been able to make photonic hydrogels that respond to stimuli, chiral porous silica that can be used to separate enantiomers, and photonic plastics that can be imprinted with photonic patterns. During our most recent NSERC Discovery Grant period, we have made several other significant contributions in the field of supramolecular chemistry and materials, including development of campestarenes, a class of molecules with 5-fold symmetry; discovery of hexagonal nanotubular assemblies from triptycene derivatives using OH---Br bonding; and a detailed understanding of tautomerization in imines formed from triformylphloroglucinol. In this proposal, we build on our past accomplishments to investigate a new concept, using rigid, shape-persistent macrocycles as templates to construct polymetallic complexes and nanofibres. We will investigate the synthesis and characterization of rigid macrocycles and cleft-shaped molecules. These will be functionalized to form superligands that are designed to host polymetallic complexes. The coordination chemistry, aggregation, and molecular dynamics of the new organic molecules will be investigated. The long term goal is to use the macrocycles as templates for constructing metal and metal oxide nanowires that may become part of future computer technology. As well, we hope that the molecular complexes will serve as mimics for metalloenzymes, offering unique electronic, optical, magnetic, and catalytic properties that we can explore. This Discovery grant will train students at all levels: graduate, undergraduate, and post-doctorate. HQP involved in the proposed work will receive world-class training in a dynamic, multidisciplinary research environment that includes opportunities to interact with industry and take part in professional development workshops and opportunities. In addition to receiving hands-on training on extensive equipment available, trainees will work on challenging projects that stimulate their curiosity and acumen in science, best preparing them for their careers.

超分子化学是1987年诺贝尔化学奖（以及2016年诺贝尔化学奖的基础）的主题，是一个蓬勃发展的领域，它利用了弱分子间相互作用，从更简单的构建基础中创建复杂的结构。这是自然的方式：从自下而上建立复杂性。 使用超分子方法，化学家正在建立分子结，晶体管和传感器，仅举几个令人兴奋的发展。 在我们的研究计划中，我们使用超分子模板来构建复杂的材料。例如，将纤维素纳米晶体（CNC）作为模板，我们能够制造出对刺激，手性多孔二氧化硅反应的光子水凝胶，可用于分离映异构体和可以用光子模式刻印的光子塑料。在最近的NSERC发现赠款期间，我们在超分子化学和材料领域做出了其他重大贡献，包括开发campestarenes，这是一类具有5倍对称性的分子。使用OH --- BR键从三联苯衍生物中发现六边形纳米管组件；并详细了解由三膜基氯葡萄醇形成的肌氨酸化。 在此提案中，我们以过去的成就为基础，以使用刚性的，形状持久的大环作为模板来构建聚合金属络合物和纳米纤维的新概念。我们将研究刚性大环和裂变分子的合成和表征。这些将被功能化以形成旨在托管聚合金属络合物的高级材料。将研究新有机分子的配位化学，聚集和分子动力学。长期目标是将大环用作可能成为未来计算机技术的一部分的金属和金属氧化物纳米线的模板。同样，我们希望分子络合物将作为金属酶的模拟物，提供我们可以探索的独特电子，光学，磁性和催化性能。 这项发现赠款将在各个层面上培训学生：毕业生，本科生和后训练。参与拟议工作的HQP将在动态的多学科研究环境中接受世界一流的培训，其中包括与行业互动并参加专业发展研讨会和机会的机会。除了接受可用的广泛设备上的动手培训外，学员还将致力于挑战他们在科学领域的好奇心和敏锐度的挑战项目，最好为他们的职业做准备。