New Directions in Supramolecular and Coordination Chemistry

超分子与配位化学的新方向

• 批准号: RGPIN-2017-04899
• 负责人: MacLachlan, Mark
• 金额: $ 9.03万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=710882
• 关键词: New; Directions; Supramolecular; Coordination; Chemistry

Supramolecular chemistry, the subject of the 1987 Nobel Prize in Chemistry (and the basis of the 2016 Nobel Prize in Chemistry), is a flourishing field that exploits weak intermolecular interactions to create complex structures from simpler building blocks. This is Nature's way: building complexity from the bottom up. Using supramolecular approaches, chemists are building molecular knots, transistors, and sensors, to name only a few of the exciting developments. In our research program, we use supramolecular templating to construct complex materials. For example, using cellulose nanocrystals (CNCs) as templates, we have been able to make photonic hydrogels that respond to stimuli, chiral porous silica that can be used to separate enantiomers, and photonic plastics that can be imprinted with photonic patterns. During our most recent NSERC Discovery Grant period, we have made several other significant contributions in the field of supramolecular chemistry and materials, including development of campestarenes, a class of molecules with 5-fold symmetry; discovery of hexagonal nanotubular assemblies from triptycene derivatives using OH---Br bonding; and a detailed understanding of tautomerization in imines formed from triformylphloroglucinol. In this proposal, we build on our past accomplishments to investigate a new concept, using rigid, shape-persistent macrocycles as templates to construct polymetallic complexes and nanofibres. We will investigate the synthesis and characterization of rigid macrocycles and cleft-shaped molecules. These will be functionalized to form superligands that are designed to host polymetallic complexes. The coordination chemistry, aggregation, and molecular dynamics of the new organic molecules will be investigated. The long term goal is to use the macrocycles as templates for constructing metal and metal oxide nanowires that may become part of future computer technology. As well, we hope that the molecular complexes will serve as mimics for metalloenzymes, offering unique electronic, optical, magnetic, and catalytic properties that we can explore. This Discovery grant will train students at all levels: graduate, undergraduate, and post-doctorate. HQP involved in the proposed work will receive world-class training in a dynamic, multidisciplinary research environment that includes opportunities to interact with industry and take part in professional development workshops and opportunities. In addition to receiving hands-on training on extensive equipment available, trainees will work on challenging projects that stimulate their curiosity and acumen in science, best preparing them for their careers.

超分子化学是 1987 年诺贝尔化学奖的主题（也是 2016 年诺贝尔化学奖的基础），是一个蓬勃发展的领域，它利用弱的分子间相互作用，从更简单的构建单元创建复杂的结构。这是大自然的方式：自下而上构建复杂性。 化学家正在利用超分子方法构建分子结、晶体管和传感器，仅举几个令人兴奋的进展。 在我们的研究项目中，我们使用超分子模板来构建复杂材料。例如，使用纤维素纳米晶体（CNC）作为模板，我们已经能够制造出对刺激做出反应的光子水凝胶、可用于分离对映体的手性多孔二氧化硅以及可印有光子图案的光子塑料。在我们最近的 NSERC 发现资助期间，我们在超分子化学和材料领域做出了其他几项重大贡献，包括开发油菜烯，一类具有 5 重对称性的分子；利用OH---Br键合从三蝶烯衍生物中发现六方纳米管组件；以及对三甲酰间苯三酚形成的亚胺互变异构的详细了解。 在这项提案中，我们在过去的成就的基础上研究了一个新概念，使用刚性的、形状持久的大环化合物作为模板来构建多金属配合物和纳米纤维。我们将研究刚性大环和裂口状分子的合成和表征。这些将被功能化以形成旨在承载多金属络合物的超级配体。将研究新有机分子的配位化学、聚集和分子动力学。长期目标是使用大环化合物作为构建金属和金属氧化物纳米线的模板，这些纳米线可能成为未来计算机技术的一部分。此外，我们希望分子复合物能够作为金属酶的模拟物，提供我们可以探索的独特的电子、光学、磁性和催化特性。 这笔发现补助金将培训各个级别的学生：研究生、本科生和博士后。参与拟议工作的总部将在充满活力的多学科研究环境中接受世界一流的培训，其中包括与行业互动以及参加专业发展研讨会的机会和机会。除了接受有关大量可用设备的实践培训外，学员还将参与具有挑战性的项目，激发他们对科学的好奇心和敏锐度，为他们的职业生涯做好最好的准备。