Preparation, isolation, and characterization of fragile acid-base complexes including intermediates of potential biological relevance

脆弱酸碱复合物的制备、分离和表征，包括具有潜在生物相关性的中间体

• 批准号: RGPIN-2016-04204
• 负责人: Clyburne, Jason
• 金额: $ 2.62万
• 依托单位: Saint Mary's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=709049
• 关键词: Preparation; isolation; characterization; fragile; acid

The chemical behavior of small reactive gases such as carbon dioxide and the sulfur oxides is important on the large-scale vis-à-vis global warming and acid rain. Often overlooked is their role in materials and in biological systems. In order to understand more of this chemistry, we are systematically exploring the reactivity of these small gaseous molecules in a wide variety of environments, including unusual solvents and also within porous materials. This exploration can be guided by the use of coordination chemistry, a process wherein a small molecule or ion donates electrons to the reactive gas. When an interaction occurs a new bond is formed, which often results in significant modification of the behavior and reactivity of the parent gas. In the case of strong interactions, the product molecules can sequester the gas. In the case of weak interactions, the chemistry of the gaseous molecule may be altered but the gas can subsequently be released because it is only weakly held. In this proposal we outline our plan to explore the chemistry of carbon dioxide, carbon disulfide, sulfur dioxide and sulfur trioxide in a wide variety of chemical environments. As mentioned above, this chemistry will be important for our understanding of these industrial gases on a large-scale. The studies in new and unusual media will provide valuable insight as to how nature handles these important molecules within, for example, the active sites of enzymes, i.e., on a much smaller scale.

小反应性气体（例如二氧化碳和硫氧化物）的化学行为对于相对于全球变暖和酸雨的大规模重要。通常被忽视的是它们在材料和生物系统中的作用。为了了解更多的化学性质，我们正在系统地探索这些小气体分子在各种环境中的反应性，包括异常溶液以及多孔材料中的反应性。可以通过使用协调化学来指导这种探索，这一过程中，小分子或离子将电子捐赠给反应性气体。当发生相互作用时，形成了新的键，这通常会导致对父气体的行为和反应性的显着修改。在强烈相互作用的情况下，产物分子可以隔离气体。在相互作用较弱的情况下，气态分子的化学性能可能会改变，但由于仅弱持有气体，因此可以释放气体。 在此提案中，我们概述了在各种化学环境中探索二氧化碳，二硫化碳，二氧化硫和三氧化硫化学的计划。如上所述，这种化学对于我们在大规模上对这些工业气体的理解非常重要。新的和不寻常的培养基中的研究将提供有价值的见解，即自然如何处理这些重要分子，例如酶的活性位点，即以较小的规模。