B cell-intrinsic insulin resistance as a mechanism of obesity-linked immune dysfunction

B 细胞内在胰岛素抵抗是肥胖相关免疫功能障碍的机制

• 批准号: 443920
• 负责人: Tsai Sue Y
• 金额: $ 60.47万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-04-01 至 2026-04-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=443920&lang=en
• 关键词: Anti-Viral Immunity; B Lymphocytes; Diabetes; Insulin Resistance; Metabolism; Obesity

Obesity predisposes to insulin resistance (IR), a state where the body responds poorly to the metabolic hormone, insulin. Obesity/IR pose a significant global health threat, as the accompanying inflammatory changes in obese individuals sprout serious heal

肥胖容易出现胰岛素抵抗（IR），这是一种身体对代谢激素胰岛素反应不佳的状态。肥胖/IR对全球健康构成重大威胁，因为肥胖者伴随的炎症变化会严重痊愈