Rampable Intraoperative Magnetic Resonance Imaging

可倾斜术中磁共振成像

• 批准号: 555261-2020
• 负责人: Martin, Melanie
• 金额: $ 7.29万
• 依托单位: University of Winnipeg
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705605
• 关键词: Rampable; Intraoperative; Magnetic; Resonance; Imaging

MRI scanners generate exquisitely detailed images of brain and spinal cord anatomy and pathology. Although an engineering challenge, the placement of MRI systems in the operating room will revolutionize neurosurgical care. The first commercial iMRI systems were developed by GE based on a 0.5 Tesla magnet with Brigham and Women's hospital in Boston. In 1988 a group in Winnipeg (IMRIS) developed an iMRI system based on a 1.5 Tesla magnet which overcame many of the difficult issues discovered with the GE system. The iMRI technology enabled neurosurgeons to improve surgeries and outcomes. Intraoperative MRI has also identified a significant number of patients who harboured unsuspected, residual tumour at the end of surgery, thus sparing them the discomfort and expense of reoperation. The major problem with the IMRIS intraoperative system which is the market leader it was is too expensive. An even more serious problem was that the cost of renovation to the hospital was much more expensive and required operating suites to be closed for months during this renovation. Our new concept is to base the iMRI on a cryogen free magnet which can be ramped to 1 tesla and is stable at this field in 10 minutes. The magnet will be made with Magnesium Diboride (MgB2) which is a high temperature superconducting material. The magnet will be continually connected to a power supply and so will not require to be persistent allowing for the rapid ramp rate. The objective of the new design is to have an intra-operative MRI that take 2 weeks to install in a standard hospital surgical suite which can provide images of the same quality as a 1.5 Tesla commercial MRI on 2012 in the same time. The important research factor being developed in this proposal is to obtain image quality equivalent or better to what was obtained with the 1.5 tesla IMRIS systems. It is well known that the signal to noise ratio (SNR) increases linearly with field strength so a 1 Tesla magnet will have about 60% of the SNR to that of 1.5 Tesla magnet. We will develop RF coils and AI techniques to improve image quality.

MRI扫描仪可产生精美的脑和脊髓解剖学和病理学图像。虽然 工程挑战，MRI系统在手术室的放置将彻底改变神经外科手术 关心。 GE基于Brigham的0.5 Tesla磁铁开发了第一个商业IMRI系统 和波士顿的妇女医院。 1988年，温尼伯（IMRIS）的一个小组开发了一个基于A的IMRI系统 1.5特斯拉磁铁，它克服了GE系统发现的许多困难问题。 IMRI 技术使神经外科医生能够改善手术和结果。术中MRI还确定了 在手术结束时，大量患有未估计的残留肿瘤的患者，因此很少 他们是重新手术的不适和费用。 IMRIS术中系统的主要问题是市场领导者太昂贵了。 一个更严重的问题是，对医院的翻新成本要昂贵得多，而且 在此翻新过程中，需要关闭几个月的经营套件。 我们的新概念是将IMRI基于无低温磁铁，该磁铁可以升至1特斯拉，并且在 该领域在10分钟内。磁铁将用二硫镁镁（MGB2）制成 温度超导材料。磁铁将不断连接到电源，因此 不需要持续允许快速坡道速率。 新设计的目的是具有术中MRI，需要2周的时间才能以标准安装 医院外科套件，可以在2012年提供与1.5特斯拉商业MRI相同质量的图像 同时。该提案中正在开发的重要研究因素是获得图像质量 等效或更好地与1.5 Tesla Imris系统获得的相等或更好。众所周知，信号到 噪声比（SNR）随场强的线性增加，因此1 Tesla磁铁将使SNR的60％至 1.5特斯拉磁铁。我们将开发RF线圈和AI技术来提高图像质量。