Modelling SARS-CoV-2 movement through a city via municipal sewage networks: Kamloops, British Columbia COVID-19 reemergence warning system pilot project

通过市政污水网络对 SARS-CoV-2 在城市中的移动进行建模：不列颠哥伦比亚省坎卢普斯 COVID-19 再次出现预警系统试点项目

• 批准号: 552454-2020
• 负责人: VanHamme, Jonathan
• 金额: $ 3.64万
• 依托单位: Thompson Rivers University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=703531
• 关键词: Modelling; SARS; CoV; movement; through

As local, regional and national governments grapple with planning for loosening physical distancing restrictions relating to the SARS-CoV-2 pandemic in the absence of a vaccine or widespread herd immunity, tools for viral monitoring at a population-wide level are essential. These tools include testing individuals for viral infection, immunological testing to detect prior viral exposure, and contact tracing. This project builds on international efforts to monitor levels of viral genetic material in community sewage collection and treatment systems. This collaboration between Thompson Rivers University, the City of Kamloops, Urban Systems Inc., the University of Regina, the British Columbia Ministry of Environment & Climate Change Strategy, with direction from the British Columbia Ministry of Health, will measure baseline population-scale levels of SARS-CoV-2 genetic material for the city of Kamloops, and targeted sub-populations in Kamloops using samples from the sewage collection network. This information will be put in context of viral outbreak data collected by local health authorities, such that continual monitoring of viral levels in sewage can be used as an early indicator of viral reemergence until such a time as a vaccine is widely available. Importantly, methodologies, datasets, best practices and experiences gained here will be widely shared with communities across Canada, and with the growing network of international researchers working in this area. This work will also be informed by similar efforts that have been described for polio, norovirus and hepatitis A in countries such as Japan, Sweden and Italy.

在缺乏疫苗或广泛群体免疫的情况下，地方、地区和国家政府正在努力制定放宽与 SARS-CoV-2 大流行相关的身体距离限制的计划，因此在人群层面进行病毒监测的工具至关重要。这些工具包括测试个人是否感染病毒、检测先前病毒暴露的免疫学测试以及接触者追踪。该项目建立在监测社区污水收集和处理系统中病毒遗传物质水平的国际努力的基础上。汤普森河大学、坎卢普斯市、Urban Systems Inc.、里贾纳大学、不列颠哥伦比亚省环境与气候变化战略部之间的合作，在不列颠哥伦比亚省卫生部的指导下，将测量基线人口规模水平坎卢普斯市的 SARS-CoV-2 遗传物质，以及使用污水收集网络中的样本针对坎卢普斯的亚群进行了研究。这些信息将被纳入当地卫生当局收集的病毒爆发数据的背景下，以便对污水中病毒水平的持续监测可以用作病毒重新出现的早期指标，直到疫苗得到广泛使用。重要的是，这里获得的方法、数据集、最佳实践和经验将与加拿大各地的社区以及该领域不断增长的国际研究人员网络广泛分享。这项工作还将参考日本、瑞典和意大利等国针对脊髓灰质炎、诺如病毒和甲型肝炎所做的类似努力。