Defining the role of tissue resident immune cells in promoting or inhibiting ischemia reperfusion injury (IRI) and poorer clinical outcomes in kidney transplantation.

定义组织驻留免疫细胞在促进或抑制缺血再灌注损伤（IRI）和肾移植中较差临床结果中的作用。

• 批准号: 449340
• 负责人: Mak Martin L
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449340&lang=en
• 关键词: Deceased Donor; Differences Between Deceased And Living; Graft Function; Graft Rejection; Immune Cell Differences; Ischemia Reperfusion Injury; Kidney; Rnaseq; Transplantation; Transplantation Injury

Ischemia reperfusion injury (IRI) refers to damage caused when blood supply returns to an organ after oxygen deprivation, which can lead to severe malfunction of the organ. Notably, patients who receive kidney transplants from deceased donors have higher

缺血再灌注损伤（IRI）是指器官缺氧后血液供应恢复时造成的损伤，可导致器官的严重功能障碍。值得注意的是，接受已故捐献者肾移植的患者的肾移植率更高