Investigation of ion-coupled solute cotransport: Structure/function studies of the rabbit Na+/D-glucose cotransporter (SGLT1)

离子耦合溶质协同转运的研究：兔 Na /D-葡萄糖协同转运蛋白 (SGLT1) 的结构/功能研究

• 批准号: 178994
• 负责人: Silverman Melvin
• 金额: $ 7.29万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2009-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=178994&lang=en
• 关键词: Chemical Modification By Methanethiosulphonate Derivatives; Cos-7 Cell Expression; Cysteine Mutagenesis; Electrophysiology Using 2-Electrode Voltage Clamp; Fluorescence; Ion-Coupled Solute Cotransport; Isotope Uptake

Our focus is a unique protein called SGLT1, expressed on the surface of cells in the intestine, kidney and lung. By an as yet unknown mechanism, SGLT1 transports in a tightly coupled fashion two Na+ ions and one sugar molecule, from the exterior into

我们的重点是一种称为 SGLT1 的独特蛋白质，它在肠、肾和肺细胞表面表达。通过一种目前未知的机制，SGLT1 以紧密耦合的方式将两个 Na+ 离子和一个糖分子从外部运输到