Rapid Delivery of Therapeutics Via Dissolution of Polymeric Films

通过聚合物薄膜的溶解快速递送治疗药物

• 批准号: 539432-2019
• 负责人: Adronov, Alex
• 金额: $ 8.74万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699557
• 关键词: Rapid; Delivery; Therapeutics; Via; Dissolution

Oral delivery of pharmaceuticals is the most common form of drug administration, and is dominated by the use of tablets and capsules of various forms. However, there are a number of problems associated with tablets that diminish the utility of this form of dose administration. For instance, patients that have difficulty swallowing (children, the elderly, people with severe nausea, and patients suffering from dysphasia) are unable to tolerate solid tablets. In addition, tablets must pass through the gastrointestinal tract, with the therapeutic agents being absorbed through the gut. This takes significant amounts of time, delaying the onset of therapeutic action. Finally, drugs that are swallowed generally undergo metabolism, and can cause liver toxicity. As an alternative to tablets, thin polymer films that rapidly dissolve in the mouth have received significant attention. These films have been introduced in the market by Pfizer as Listerine PocketPaks, and have been a popular breath freshener since 2001. However, these films can also be loaded with pharmaceutical agents for oral drug delivery. This allows a therapeutic dose to be released in the mouth, and to be absorbed through the mucosal membranes directly into the bloodstream, bypassing the stomach and liver. This is advantageous as it results in rapid entry of drugs into circulation, bypasses gastrointestinal metabolism, decreases liver toxicity, and does not require swallowing. However, loading different drug compounds, especially those that are not water soluble, within a rapidly dissolving thin polymer film poses challenges, as different structures will impact film integrity and properties. This proposal aims to investigate new formulations for incorporation and encapsulation of a wide array of drugs within polymer films, and to help the industrial partner (Rapid Dose Therapeutics, Inc.) develop alternative delivery methods for the pharmaceutical industry.

药物的口服输送是药物管理的最常见形式，它以各种形式的片剂和胶囊的使用为主。 但是，与片剂相关的许多问题会削弱这种剂量给药形式的效用。 例如，吞咽困难的患者（儿童，老年人，严重的恶心和患有不症状的患者）无法忍受固体片剂。 此外，片剂必须通过胃肠道，而治疗剂通过肠道吸收。 这需要大量时间，从而延迟了治疗作用的发作。 最后，吞咽的药物通常会发生代谢，并可能引起肝脏毒性。 作为片剂的替代方法，迅速溶于口腔的薄聚合物膜受到了极大的关注。 这些电影是由辉瑞公司（Pfizer）作为李斯特琳（Listerine）Pocketpaks推出的，自2001年以来一直是流行的呼吸清新剂。但是，这些电影也可以装有用于口服药物的药物。 这样可以将治疗剂量释放到口腔中，并通过粘膜膜直接吸收到血液中，绕过胃和肝脏。 这是有利的，因为它导致药物迅速进入循环，绕过胃肠道代谢，降低肝脏毒性，并且不需要吞咽。 然而，在快速溶解的薄聚合物膜中加载不同的药物化合物，尤其是那些不是水溶性的药物，会带来挑战，因为不同的结构会影响膜的完整性和特性。 该建议旨在调查在聚合物膜中纳入和封装各种药物的新配方，并帮助工业合作伙伴（Rapid Dose Therapeutics，Inc。）开发为制药行业开发替代性递送方法。