Developmental Neurobiology

发育神经生物学

• 批准号: CRC-2019-00291
• 负责人: Mizumoto, Kota
• 金额: $ 7.29万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695500
• 关键词: Developmental; Neurobiology

My research program aims at understanding how nerve cells (neurons) communicate with their neighboring cells to form a functional neural network. Neurons communicate with their target cells via specialized interface called synapses. Miscommunication between neurons cause various neurological conditions which are detrimental to those affected and their family. Toward this I use neurons of the genetic model organism, Caenorhabditis elegans, to elucidate the genetic and molecular mechanisms that underlie where and how neurons form synapses. Our findings will help other researchers to test if similar mechanisms is present in animal models with more complex nervous system such as mouse.

我的研究项目旨在了解神经细胞（神经元）如何与邻近细胞通信以形成功能性神经网络。神经元通过称为突触的特殊接口与其目标细胞进行通信。神经元之间的沟通不畅会导致各种神经系统疾病，这对受影响的人及其家人有害。为此，我使用遗传模型生物体秀丽隐杆线虫的神经元来阐明神经元形成突触的位置和方式的遗传和分子机制。我们的发现将帮助其他研究人员测试类似的机制是否存在于具有更复杂神经系统的动物模型（例如小鼠）中。