High-Resolution Modeling in Systems Biology

系统生物学中的高分辨率建模

• 批准号: CRC-2015-00042
• 负责人: Xia, Yu
• 金额: $ 14.57万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695501
• 关键词: Resolution; Modeling; Systems; Biology

The research program of the CRC in High-Resolution Modeling in Systems Biology aims to construct accurate, genome-scale, atomic-resolution three-dimensional structural models for nodes and edges within protein-protein interaction networks in model eukaryotic species, in human, and between proteins from different species. This is achieved by developing key enabling computational technologies for high-resolution systems biology, and by collaborating with leading experimental systems biologists. These high-resolution models of cell circuitry will be used to probe design principles of biological networks, and to elucidate systems-level mechanisms of both human infectious and genetic diseases.

CRC 系统生物学高分辨率建模研究项目旨在为模型真核物种、人类和人类的蛋白质-蛋白质相互作用网络中的节点和边缘构建准确的、基因组规模的、原子分辨率的三维结构模型。来自不同物种的蛋白质之间。这是通过开发高分辨率系统生物学的关键计算技术并与领先的实验系统生物学家合作来实现的。这些高分辨率的细胞电路模型将用于探索生物网络的设计原理，并阐明人类传染病和遗传疾病的系统级机制。