Organic Synthesis and Biocatalysis

有机合成与生物催化

• 批准号: CRC-2016-00268
• 负责人: Hudlicky, Tomas
• 金额: $ 14.57万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694470
• 关键词: Organic; Synthesis; Biocatalysis

Our research program focuses on efficient manufacturing of medicinally importantcompounds by combining traditional organic synthesis methods with biological protocols, a strategy that leads to more efficient and environmentally conscious manufacturing with less waste. It addresses the preparation of morphine alkaloids, including semisynthetic opiate-derived agents (analgesics); pancratistatin derivatives and pleiogenone A (anticancer agents); and other targets (galanthamine) by using bacterial, fungal, plant, or mammalian enzymes as green alternatives to the use of hazardous or toxic reagents. Reagent development, total synthesis, development of transgenic organisms for N-demethylation, and provision of enantiopure building blocks and chiral polymers characterize our program in biocatalysis.

我们的研究项目侧重于通过将传统有机合成方法与生物方案相结合来高效制造具有重要药用价值的化合物，该策略可实现更高效、更环保、更少浪费的制造。它涉及吗啡生物碱的制备，包括半合成阿片衍生剂（镇痛药）； pancratistatin衍生物和pleiogenone A（抗癌剂）；通过使用细菌、真菌、植物或哺乳动物酶作为使用危险或有毒试剂的绿色替代品来实现其他目标（加兰他敏）。试剂开发、全合成、N-去甲基化转基因生物的开发以及对映体纯结构单元和手性聚合物的提供是我们生物催化项目的特点。