Boron Chemistry for Catalysis and Drug Discovery

用于催化和药物发现的硼化学

• 批准号: CRC-2015-00074
• 负责人: Hall, Dennis
• 金额: $ 14.57万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694225
• 关键词: Boron; Chemistry; Catalysis; Drug; Discovery

Organoboron chemistry, the study of organic compounds containing carbon-boron bonds, plays a key role by providing chemical reactions that are changing the way synthetic drugs are produced in the pharmaceutical industry. The nominee is an expert on fundamental research and applications of boronic acids, a stable and convenient class of boron compounds that display unique properties and can be turned reactive under the right conditions. Using novel chemistry of boronic acids, the goal of the proposed program is two-fold: 1) to invent new reactions and new catalysts to achieve or improve chemical reactions that are environmentally friendlier ("greener") and more cost-effective, 2) to translate these discoveries into solutions for real-life problems in areas such as human health (i.e., cancer chemotherapeutics). These challenges will be tackled by developing novel carbon-carbon bond forming reactions to access and optimize classes of molecules that display anticancer properties.

有机硼化学是对含有碳硼键的有机化合物的研究，通过提供改变制药行业合成药物生产方式的化学反应发挥着关键作用。被提名者是硼酸基础研究和应用方面的专家，硼酸是一类稳定且方便的硼化合物，具有独特的性质，并且可以在适当的条件下变成反应性的。 利用硼酸的新型化学，该计划的目标有两个：1）发明新反应和新催化剂，以实现或改进更环保（“更绿色”）和更具成本效益的化学反应，2）将这些发现转化为人类健康等领域现实生活问题的解决方案（即癌症化疗）。这些挑战将通过开发新型碳-碳键形成反应来解决，以获取和优化具有抗癌特性的分子类别。