Synergising nanoemulsion and lipid biomimetic design for advanced delivery

协同纳米乳液和脂质仿生设计以实现先进的递送

• 批准号: LP220200944
• 负责人: A/Prof Natalie Trevaskis
• 金额: $ 42.7万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP220200944
• 关键词: Synergising; nanoemulsion; lipid; biomimetic; design

This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens derived from food and the microbiome. The project will deliver a design roadmap of the required characteristics for lymphatic targeting, and in particular, will identify novel lipid nanoemulsions that work synergistically with lipid biomimetics to enhance lymphatic imaging and delivery applications.

该项目旨在确定脂质修饰探针或药物（脂质仿生学）的脂质制剂的关键设计特征，这些探针或药物共同促进整合到脂质吸收途径中并靶向引流小肠的淋巴系统。这具有巨大的潜力，因为肠道淋巴系统是关键的免疫组织，是对自身抗原以及源自食物和微生物组的抗原产生免疫反应的部位。该项目将提供淋巴靶向所需特性的设计路线图，特别是确定与脂质仿生剂协同作用的新型脂质纳米乳剂，以增强淋巴成像和输送应用。