Determining the mechanisms of HIV-1 Vpu-mediated antagonism of Tim-3

确定 HIV-1 Vpu 介导的 Tim-3 拮抗机制

• 批准号: 428783
• 负责人: Edgar Cassandra R
• 金额: $ 1.27万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428783&lang=en
• 关键词: Anti-Retroviral Targets; Hiv-1; Hiv-1 Vpu; Host Restriction Mechanisms; Intracellular Trafficking; Microscopy; Multiplex Cytokine Assay; T Cell Exhaustion; T Cell Receptor Signalling; Tim-3

"Human Immunodeficiency Virus-Type 1 (HIV-1) currently infects over 36 million individuals globally. Although HIV-1 transmission potential and symptoms can be reduced by anti-retroviral therapy (ART), there remains a need for new ARTs to treat those resis

“人类免疫缺陷病毒 1 型 (HIV-1) 目前在全球感染超过 3600 万人。尽管抗逆转录病毒疗法 (ART) 可以减少 HIV-1 的传播潜力和症状，但仍然需要新的 ART 来治疗这些疾病抵抗力