Development and validation of novel bioactive biodegradable metals for high performance biomaterials

用于高性能生物材料的新型生物活性可生物降解金属的开发和验证

• 批准号: RGPIN-2017-04274
• 负责人: Hermawan, Hendra
• 金额: $ 1.75万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=679639
• 关键词: Development; validation; novel; bioactive; biodegradable

The dream of biomedical device industries is to provide patients and clinicians with a new generation of implants that can perform its function then dissolve in the host body, eliminating the harmful effects of current permanent implants. Biodegradable metals, having the combination of strength, ductility and degradability, have been viewed as the ideal materials for making those dreamed implants. Published works on biodegradable metals have been significantly increasing from less than 50 papers in 2005 to more than 2,000 over 10 years. These metals have been attracting researchers in academia and industries alike as they can potentially revolutionize the medical products. The future trend goes toward adding bioactivities and exploring new clinical applications that require a temporary presence of load bearing implants. One of the latest development is the introduction of its porous structure for bone scaffolds. I am among the first to introduce porous biodegradable metal scaffolds with the works on new composites of porous iron-poly(lactic-co-glycolic acid) as reported in Nature's Scientific Reports. ******Having worked independently in biodegradable metals research in the past 6 years, I defined my long-term objective to develop world-recognized expertise in novel innovative biomaterials with fundamental understanding of their material-process-corrosion relationship. Within 5 years, I will address the current challenge and need for bioactive biomaterials and explore new applications of biodegradable metals. At one direction, I will develop new class of bioactive iron-based porous metals in view of bone scaffold applications. The porous iron will be the backbone for incorporating bioactive compounds like Ca-P and Ag ions via conversion coating technique. Another direction is on developing novel biodegradable metals in view of new application in urology. Having discussed with urologists, I understood there is an unfulfilled need for strong temporary ureteral stents where engineering should take the role. Magnesium and zinc alloys are the ideal materials to make the stent with superior mechanical property than that made of polymers. The works in both directions are intended to make a lasting effect by understanding process-structure-property relationship of the developed materials.******I will bring valid evidence of the optimum mechanical and corrosion properties of bioactive porous iron and novel alloys as new technological platform applicable to scaffold and ureteral stents, respectively. I will both advance knowledge and train high qualified personnel to acquire expertise in the key areas of science and engineering for Canada. Four graduate students were recruited and have been initiating works planned in this program with some preliminary results. The support from NSERC plays an important role to the continuation of their training and the establishment of our young research group.

生物医学设备行业的梦想是为患者和临床医生提供可以执行其功能然后溶解在宿主体内的新一代植入物，从而消除了当前永久植入物的有害影响。可生物降解的金属具有强度，延展性和降解性的结合，已被视为使这些梦植入物的理想材料。关于可生物降解金属的发表著作已从2005年的少于50篇论文中显着增加到10年以上的2,000多篇。这些金属一直在吸引学术界和行业的研究人员，因为它们可能会彻底改变医疗产品。未来的趋势将用于增加生物活性和探索需要暂时存在负荷轴承植入物的新临床应用。最新的发展之一是引入其用于骨支架的多孔结构。我是最早在自然科学报告中报道的多孔铁聚（乳酸 - 乙醇酸）上的新复合材料的作品中引入多孔可生物降解金属支架的人之一。 *****在过去6年中，我在可生物降解的金属研究中独立工作，我定义了自己的长期目标，以开发新型创新生物材料方面的世界认可的专业知识，并对他们的物质处理 - 腐败关系的基本了解。在5年内，我将解决当前对生物活性生物材料的挑战和需求，并探索可生物降解金属的新应用。在一个方向上，鉴于骨支架的应用，我将开发新的生物活性铁金属。多孔铁将是通过转化涂层技术结合生物活性化合物（例如CA-P和Ag ION）的主链。鉴于泌尿科中的新应用，另一个方向是开发新型的可生物降解金属。与泌尿科医生讨论后，我了解到没有实现强大的临时输尿管支架，工程应该扮演角色。镁和锌合金是使支架具有优质机械特性的理想材料，而不是由聚合物制成的理想材料。这两个方向的作品均旨在通过了解开发材料的过程结构 - 特制关系来产生持久的效果。作为新技术平台，分别适用于脚手架和输尿管支架。我将提高知识并培训高素质的人员，以在加拿大的科学和工程领域获得专业知识。招募了四名研究生，并一直在该计划中启动计划的作品，并有一些初步的结果。 NSERC的支持对于继续培训和我们年轻研究小组的建立起着重要作用。