Radionuclide-based bioorthogonal click chemistry for targeted molecular imaging and therapy

基于放射性核素的生物正交点击化学用于靶向分子成像和治疗

• 批准号: RGPIN-2014-04318
• 负责人: Wuest, Frank
• 金额: $ 2.48万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669003
• 关键词: Radionuclide; based; bioorthogonal; click; chemistry

Cancer is a major public health problem. Currently, one in four deaths in the United States and Canada is due to cancer. Modern bioorganic and medicinal chemistry concepts aim at the development of novel tool to detect and treat cancer more efficiently. The proposed research project deals with the development of novel radiochemistry concepts and the design and synthesis of novel radiolabeled compounds to fulfill the promise of molecular imaging and targeted radiotherapy to improve patient care. The project will explore so-called click chemistry as highly innovative chemistry tool for the development of radiolabeled compounds for applications in medical research and mediacal practice. The term click chemistry defines a powerful set of chemical reactions to create heteroatom C-X-C links enabling the rapid, selective and high-yielding labeling of biomolecules. The proposed research project has the potential to open new avenues for improved diagnosis and therapy of human diseases, and to support the process of drug development. The project represents an innovative platform for the development and application of novel radiopharmaceuticals to enhance patient care.

癌症是一个主要的公共卫生问题。目前，美国和加拿大的四分之一死亡是由于癌症。现代的生物有机和药物化学概念旨在开发新型工具，以更有效地检测和治疗癌症。拟议的研究项目介绍了新型放射化学概念的发展以及新型放射性标记化合物的设计和合成，以实现分子成像和靶向放射疗法的承诺，以改善患者护理。该项目将探索所谓的点击化学作为高度创新的化学工具，用于开发用于医学研究和媒介实践中应用的放射性标记化合物。 Click Chemistr一词定义了一组强大的化学反应，以创建杂原子C-X-C链接，从而实现生物分子的快速，选择性和高收益标签。拟议的研究项目有可能开放新的途径，以改善人类疾病的诊断和治疗，并支持药物开发过程。该项目代表了开发和应用新型放射性药物以增强患者护理的创新平台。