Identification of iron oxide nanoparticle size and shape for the most effective anti-microbial/anti-biofilm activity

鉴定氧化铁纳米颗粒的尺寸和形状以实现最有效的抗微生物/抗生物膜活性

• 批准号: 531280-2018
• 负责人: vanLierop, Johan
• 金额: $ 1.82万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667540
• 关键词: Identification; iron; oxide; nanoparticle; size

The rise in antibiotic resistance is a global health-care problem [WHO - Antimicrobial resistance: Global report**on surveillance 2014]. There is a critical need for new strategies to combat infections. Topical biocides are a**possible solution to many hospital-acquired infections as they may be applied directly to the point of infection**and have a broad spectrum of microbial targets. However, they are not target specific - cytotoxicity is a**problem. This challenge may be addressed by coating magnetic nanoparticles (MNPs) with a biocide, enabling**removal from the infection site using a magnet field, and controlling contact time. To enable this technology**requires detailed insight into coating-chemistry, the MNPs magnetism, and the size and shape of MNPs to use.**Bacterial biofilms also cause tremendous infection problems. Biofilms consist of a community of**microorganisms with an extracellular matrix, and can be very difficult to remove as standard antibiotics and**disinfectants poorly penetrate the biofilm to kill or inhibit pathogenic microorganisms. Biofilms are perpetually**present on medical devices and wounds, and are a source of persistent and recurrent infections. With Kane**Biotech, my group is tackling this "biofilm problem" using new MNPs my group develops to create new**technologies for biofilm eradication using static and dynamic magnetic fields with the MNPs. Kane Biotech is**a Canadian company focused on novel products that prevent and disperse bacterial biofilms. For over 15 years**Kane Biotech's R&D division has been developing new technologies and innovations leading to over 75**patents and patents pending in biotechnology focusing primarily on biofilms. Through this Engage Grant, with**Kane, together we will apply our MNP and biofilm eradication research to establish the appropriate size and**shape of nanoparticles necessary to make possible biofilm eradication. The nanoparticle technology developed**during this Engage Grant will be adopted into Kane's portfolio of human and animal health technologies to be**leveraged into new ways to address those areas' biofilm problem.

抗生素耐药性的上升是一个全球性的卫生保健问题[世界卫生组织 - 抗生素耐药性：2014 年全球监测报告**]。迫切需要新的策略来对抗感染。外用杀菌剂是许多医院获得性感染的可能解决方案，因为它们可以直接应用于感染点**并且具有广泛的微生物目标。然而，它们不是针对特定目标的——细胞毒性是一个**问题。这一挑战可以通过用杀菌剂涂覆磁性纳米颗粒（MNP）、使用磁场从感染部位去除并控制接触时间来解决。为了实现这项技术**需要详细了解涂层化学、MNP 磁性以及要使用的 MNP 的大小和形状。**细菌生物膜也会引起巨大的感染问题。生物膜由带有细胞外基质的**微生物群落组成，并且很难去除，因为标准抗生素和**消毒剂很难渗透生物膜以杀死或抑制病原微生物。生物膜永久存在于医疗设备和伤口上，是持续性和复发性感染的来源。通过 Kane**Biotech，我的团队正在使用新的 MNP 来解决这个“生物膜问题”，我的团队开发了新的**技术，利用 MNP 的静态和动态磁场来消除生物膜。凯恩生物技术公司是**一家加拿大公司，专注于预防和分散细菌生物膜的新型产品。 15 年来**Kane Biotech 的研发部门一直在开发新技术和创新，在生物技术领域拥有超过 75** 项专利和正在申请的专利，主要关注生物膜。通过这项参与资助，我们将与**凯恩一起应用我们的 MNP 和生物膜根除研究，以确定实现生物膜根除所需的适当尺寸和**形状的纳米颗粒。在本次参与资助期间开发的纳米颗粒技术将被采用到凯恩的人类和动物健康技术组合中，以**利用新方法来解决这些地区的生物膜问题。