Making sense of highly-disturbed blood flow dynamics

理解高度扰动的血流动力学

• 批准号: RGPIN-2018-04649
• 负责人: Steinman, David
• 金额: $ 4.66万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665910
• 关键词: Making; sense; highly; disturbed; blood

The way blood flows in the body (hemodynamics) is widely thought to have a big impact on vascular diseases like atherosclerosis and aneurysms, the leading causes of heart attacks and strokes. Unfortunately, the complex hemodynamics associated with these diseases are difficult to measure directly, which has led to increasing use of computer simulations of blood flow tied to medical images of the patient, something we call image-based computational fluid dynamics (CFD).******In the last five years my team and I have uncovered strong evidence that hemodynamics may be more complex that many doctors and engineers think. Textbooks tell us that blood flow is mostly orderly (laminar), and only rarely chaotic (turbulent), which has allowed us to take convenient shortcuts to speed up CFD simulations. By not taking these shortcuts, we have found that high-frequency flow fluctuations can arise during parts of the heartbeat, and may or may not look the same in the next beat. While turbulent blood flow is known to aggravate the cells that make up vessel walls and blood, it remains unclear whether these not-quite-turbulent pulsatile flows, which we term “highly disturbed”, are equally troublesome. To understand that, we must first shed some light on the nature of these flows, which are not well studied because they fall between the laminar and turbulent flows that engineers usually deal with. This is the main goal of my proposed NSERC Discovery research.******First, we will figure out how to visualize these highly time-varying, three-dimensional (so, four dimensional) flows, and to quantify their relative complexity. Because we expect these flows to be so visually complicated, we will also use sound to take advantage of humans' ability to discriminate frequencies better by ear than by eye. Second, because highly-disturbed flows are likely to be sensitive to uncertainties in the patient data that drives image-based CFD, we will use clever techniques to determine just how confident we can be in our CFD predictions. Third, because the shape of blood vessels plays a major role in determining the hemodynamics within, we will see if, in light of those uncertainties, we can predict with at least the same confidence the likelihood of highly disturbed blood flow from vessel shape alone, potentially avoiding the need for CFD in the clinic.******This basic engineering research will be carried out in parallel to my clinical research with Toronto Western Hospital on hemodynamic factors for predicting brain aneurysm rupture, providing us with the wide variety of patient data needed to meet our objectives. Ultimately, the knowledge we gain will have application to other cardiovascular diseases where highly-disturbed flows are now also being uncovered, and will provide doctors and engineers with clearer guidelines on how to adequately simulate and/or anticipate them.

血液中的血液流动的方式是心脏病发作和中风的原因。 ******在过去的五年中，我和许多医生和工程师都认为，这些动力学更为复杂我们没有服用刺激性，我们发现在下一个节拍中会出现高弹性，而turbe骨则会在turbe骨上生气，以使构成容器壁和血液的细胞加重细胞，这是脉动流动的。 ，我们认为“高度打扰” e。 ****首先，我们将弄清楚如何可视化三变化的三维（SO，四维）流，并量化它们的相对复杂性。频率比眼睛更好。在内部，我们将鉴于染上刺激的thoseict，sast sast sast与基本的高度干扰血流流动的可能性相同。最终达到目标所需的患者数据的多样性，我们获得的知识将是心血管扫描，在高度扰动的流量中也将被d，并将为医生和工程师提供有关如何充分模拟和/或预期它们的更明确的指导方针。