Patient specific biomechanical modeling of abdominal aortic aneurysm to improve aortic endovascular repair

腹主动脉瘤患者特异性生物力学模型，以改善主动脉血管内修复

• 批准号: 514049-2017
• 负责人: Soulez, Gilles
• 金额: $ 11.66万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665663
• 关键词: Patient; specific; biomechanical; modeling; abdominal

Endovascular surgery requires of special surgical tools inserted and navigated through the vascular system to reach the site of a disease remotely. This navigation and treatment are perform under video X-Ray imager called fluoroscopy. This low-power X-Ray reveals only the bones, even though the surgery is performed on the vessels. Chemical agent dye can paint momentarily the vessel, but this agent is toxic when used in high dosage. In order to help the surgeon navigate its way, we are developing with Siemens Healthineers an enhance visualization software that displays on the fluoroscopic image the vascular structures of the patient and adapts its shape by the deformation force of the endovascular tools. This can reduce the use of contrast agent, reduce the intervention time (thus reducing radiation exposure) and generally improve the surgical outcomes.*To deform the vascular structure without its visualization, we will use a mathematical function to compute the vessel shape when subjected to endovascular tools influence. This function will be based on biomechanical computer simulations performed on a large database of interventional images. Tissues of the entire abdominal region will be simplified and modeled to achieve the most realistic behaviour. Biomechanical simulations have been used in numerous medical applications as a validation tool. We want to innovate and bring this complex simulation result to a live and reactive application. This technological innovation will improve substantially the performances and reliability of image fusion assisting software and set a new standard in medical care practices.

血管内手术需要插入和导航血管系统的特殊手术工具，以远程到达疾病的部位。这种导航和处理是在称为荧光镜检查的视频X射线成像仪下进行的。这种低功率X射线仅显示骨骼，即使手术是在血管上进行的。化学剂染料可以瞬间绘制血管，但是当用于高剂量时，该药物是有毒的。为了帮助外科医生导航，我们正在西门子卫生厂开发一个增强的可视化软件，该软件在荧光镜图像上显示患者的血管结构，并通过血管内工具的变形力来适应其形状。这可以减少对比剂的使用，减少干预时间（从而减少辐射暴露）并通常改善手术结果。此功能将基于在大型介入图像数据库上执行的生物力学计算机模拟。整个腹部区域的组织将进行简化和建模，以实现最现实的行为。生物力学模拟已在众多医疗应用中用作验证工具。我们想创新并将这一复杂的模拟结果带入实时和反应性应用程序。这项技术创新将大大提高图像融合辅助软件的性能和可靠性，并在医疗实践中设定新的标准。