Elucidating the molecular mechanisms of signalling pathways

阐明信号通路的分子机制

• 批准号: RGPIN-2017-05743
• 负责人: Ingham, Robert
• 金额: $ 1.89万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=654270
• 关键词: Elucidating; molecular; mechanisms; signalling; pathways

The cells of our body constantly receive and respond to signals from their surroundings. For example, cells of the immune system respond to invading bacteria and viruses by mounting an immune response, whereas developing neuron cells react to environmental cues to make the intricate cellular connections in our brains. Critical to the ability of cells to sense and respond to their environment are signalling pathways.*** Signalling pathways consist of an array of biological molecules including proteins, lipids, RNA, and DNA. They perform the task of transmitting information within the cell, and allow cells to translate signals they receive from the environment into biological responses. My laboratory is interested in understanding how signalling molecules work together to elicit these responses. In particular, we strive to understand how the different molecules “talk” to each other in order to relay information within the cell. Through understanding how signal transduction pathways function we can address fundamental questions about how cells perceive and react to their environment. Moreover, since many diseases are caused by signalling pathways not functioning properly, our studies may provide insight into disease processes as well.

我们身体的细胞不断接收周围环境的信号并对其做出反应，例如，免疫系统的细胞通过发起免疫反应来应对入侵的细菌和病毒，而发育中的神经元细胞则对环境信号做出反应，以建立复杂的细胞连接。信号通路对细胞感知和响应环境的能力至关重要。*** 信号通路由一系列生物分子组成，包括蛋白质、脂质、RNA 和 DNA，它们执行在内部传递信息的任务。细胞，并允许细胞翻译我的实验室有兴趣了解信号分子如何协同工作以引发这些反应，特别是，我们努力了解不同的分子如何相互“交谈”以在体内传递信息。通过了解信号转导途径如何发挥作用，我们可以解决有关细胞如何感知环境并对其做出反应的基本问题。此外，由于许多疾病是由信号转导途径无法正常发挥作用引起的，因此我们的研究也可以提供对疾病过程的深入了解。