QTPlasmonics - Next generation of plasmonic integrated label free biosensing including optical, electrical and thermal active controls and readouts

QTPlasmonics - 下一代等离子体集成无标记生物传感，包括光学、电学和热学主动控制和读数

• 批准号: RGPIN-2016-05154
• 负责人: CANVA, Michael
• 金额: $ 2.62万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=646801
• 关键词: QTPlasmonics; Next; generation; plasmonic; integrated

Biosensors are becoming more and more important as the demand on health related issues requires the monitoring of more and more parameters. Within these, plasmonic biochip systems are becoming increasingly popular thanks to their ability to monitor in parallel hundreds of surface bio-interactions without the need of a labelling step and in real time allowing accessing the kinetics of these interactions.*** Since plasmonic systems are highly sensitive to a number of environmental parameters, conventional plasmonic biosensors have sought to keep these physical parameters constant as any variations lead to unwanted changes in the signal measured from the biomolecular reaction under test. Recent progress in micro- and nano-structuring of metal-dielectric interfaces has opened the way to localized control of physical parameters at very fine space and time scales. As a result, rather than maintain constant environmental conditions, one can instead envision locally controlling environmental conditions to enhance the plasmonic sensor response. The goal of this proposal is to advance the field of plasmonics by studying the effect of controlled local electrical and thermal spatial variations at the submicron scale in so-called “nanoplasmonic” systems.*** Recently, important advances have been made in both modeling of complex plasmonic structures and their fabrication. My research program over the next five years aims at capitalizing on these advances by developing novel multi-parameter systems capable of both enhancing the capabilities of current technologies and furthermore of accessing supplementary information about the bio-targets under investigation. Applications will include not only sensors addressing markers and biohazards at very low or trace concentration but also experimental characterization of their kinetics with special attention extending to enzymes and cells*** This new knowledge will lead both to better understanding and control of multi-physics plasmonic components as well as to the development of next-generation biochip sensors designed to address some of the most pressing needs in critical care, personalized medicine and drug discovery.**

由于对健康相关问题的需求需要监视越来越多的参数，生物传剂系统变得越来越重要。在这些中，等离激元的生物芯片系统越来越流行，感谢您在不需要标记步骤的情况下，在不需要标记步骤的情况下进行数百个表面生物交互的能力，并实时允许访问这些相互作用的动力学。从正在测试的生物分子反应中测量。金属界面接口的微观和纳米结构的最新进展为在非常细的时空尺度上局部控制物理参数开辟了道路。结果，人们可以不仅要维持恒定的环境条件，而可以设想局部控制环境条件以增强等离子传感器的响应。该提案的目的是通过研究所谓的“纳米质”系统中的局部电气和热空间变化的影响来推进血浆的领域。我未来五年的研究计划旨在通过开发能够增强当前技术的能力的新型多参数系统以及访问有关投资中生物目标的补充信息的新型多参数系统的限制。应用不仅包括以非常低或痕量浓度的标记和生物危害的传感器，而且还包括对其动力学的实验表征，特别关注的是酶和细胞的特殊注意力*** ***这一新知识将使多物理等离子物质组成部分更好地理解和控制下一代生物学传感器的开发，并探讨了一些差异，这些疾病的发展是一些批判性的，这些都是批判性的。