Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
基本信息
- 批准号:RGPIN-2017-04458
- 负责人:
- 金额:$ 5.39万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Supramolecular chemistry occupies the space between individual molecules and macroscopic systems in terms of complexity and functionality. Two key features of supramolecular systems are: 1) the reversible assembly of a supermolecule from molecular building blocks and 2) the co-existence of related species that compete with one another. These characteristics are those exhibited in very complex macroscopic living systems. My research aims to understand the dynamic nature of supramolecular systems and will provide the concepts necessary for rational control of these systems from the kinetic point of view. Such kinetic control, which is currently lacking, will open new ways to design functional materials, where the dynamics of the components are essential for function. The research proposed is at the forefront of fundamental studies and does not directly address any particular function, but the outcomes have implications for any supramolecular system where binding and release of building blocks is integral to function, such as membrane transport, drug delivery, catalysis, or stimuli-responsive materials. The proposed research is allied with “systems chemistry”, in which interactions of molecular building blocks produce new properties that the individual components cannot achieve on their own.***To develop and exploit inherently complicated systems, we need to develop tools to explore and manipulate the system's outcomes. The proposed work confronts the diversity of supramolecular systems, with a focus on the kinetic control of gel-forming systems.***The proposed work with cucurbit[n]urils (CB[n]s) as host systems will provide the tools to manipulate the dynamics of host-guest systems. This knowledge will lay the groundwork for rationally using kinetics to change the behaviour of systems with multiple species, which currently is not possible. The mechanistic diversity we uncovered for guest binding with CB[n]s will be explored to determine how co-adjuvant players can lead to switches in mechanism, how self-sorting systems can be diverted as they evolve, and how the residence time of guests that simultaneously bind to CB[8] can affect the formation of gels.***The mobility of small guests in gels will be studied over microscopic to macroscopic length scales to provide information focused on the gel's molecular components. This approach will uncover knowledge that is different from the macroscopic characterization usually reported for gels. This type of experiment, where the focus is on the kinetics of individual components and the relationship to the microscopic structural features of gels, is unprecedented. As a potential practical application, the proposed work will contribute to moving the development of gels away from a trial and error approach.
超分子化学在复杂性和功能性方面占据了单个分子和宏观系统之间的空间,超分子系统的两个关键特征是:1)由分子构件可逆组装超分子;2)竞争的相关物种的共存。这些特征是在非常复杂的宏观生命系统中表现出来的,我的研究旨在了解超分子系统的动态性质,并将提供从动力学角度合理控制这些系统所需的概念。目前缺乏的这种动力学控制将为设计功能材料开辟新的方法,其中组件的动力学对于功能至关重要,所提出的研究处于基础研究的前沿,并不直接解决任何特定的功能。但结果对任何超分子系统都有影响,其中结构单元的结合和释放是功能不可或缺的一部分,例如膜运输、药物输送、催化或刺激响应材料。拟议的研究与“系统化学”相关,其中。分子构件的相互作用产生单个组件无法单独实现的新特性。***为了开发和利用本质上复杂的系统,我们需要开发工具来探索和操纵系统的结果。拟议的工作面临超分子系统的多样性,重点是。凝胶形成系统的动力学控制。***以葫芦[n]脲(CB[n]s)作为宿主系统的拟议工作将提供操纵主客体系统动力学的工具。为合理运用动力学奠定基础改变具有多个物种的系统的行为,这目前是不可能的,我们将探索客体与 CB[n] 结合的机制多样性,以确定共佐剂参与者如何导致机制转换,如何自排序。系统在演化过程中可能会发生转变,以及同时与 CB[8] 结合的客体的停留时间如何影响凝胶的形成。***小客体在凝胶中的流动性将在微观到宏观的长度尺度上进行研究,以提供重点关注的信息这种方法将揭示与通常报道的凝胶宏观表征不同的知识,这种实验的重点是单个成分的动力学以及与凝胶微观结构特征的关系。作为潜在的实际应用,所提出的工作将有助于使凝胶的开发摆脱反复试验的方法。
项目成果
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Bohne, Cornelia其他文献
Characterization of the photochromism of dihydropyrenes with photophysical techniques
- DOI:
10.1016/j.jphotochemrev.2011.08.001 - 发表时间:
2011-09-01 - 期刊:
- 影响因子:13.6
- 作者:
Bohne, Cornelia;Mitchell, Reginald H. - 通讯作者:
Mitchell, Reginald H.
Effect of the guest size and shape on its binding dynamics with sodium cholate aggregates
- DOI:
10.1021/la800439m - 发表时间:
2008-08-19 - 期刊:
- 影响因子:3.9
- 作者:
Amundson, Laurie L.;Li, Rui;Bohne, Cornelia - 通讯作者:
Bohne, Cornelia
Dynamics of a supramolecular capsule assembly with pyrene.
- DOI:
10.1021/ja301278p - 发表时间:
2012-03-28 - 期刊:
- 影响因子:15
- 作者:
Tang, Hao;de Oliveira, Carla Santos;Sonntag, Gage;Gibb, Corinne L. D.;Gibb, Bruce C.;Bohne, Cornelia - 通讯作者:
Bohne, Cornelia
Guest Binding Dynamics with Cucurbit[7]uril in the Presence of Cations
- DOI:
10.1021/ja209266x - 发表时间:
2011-12-21 - 期刊:
- 影响因子:15
- 作者:
Tang, Hao;Fuentealba, Denis;Bohne, Cornelia - 通讯作者:
Bohne, Cornelia
Protein capped nanosilver free radical oxidation: role of biomolecule capping on nanoparticle colloidal stability and protein oxidation
- DOI:
10.1039/c7cc08629f - 发表时间:
2018-05-07 - 期刊:
- 影响因子:4.9
- 作者:
Ahumada, Manuel;Bohne, Cornelia;Alarcon, Emilio, I - 通讯作者:
Alarcon, Emilio, I
Bohne, Cornelia的其他文献
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{{ truncateString('Bohne, Cornelia', 18)}}的其他基金
Stopped-flow Spectrometer for Supramolecular Dynamics Studies
用于超分子动力学研究的停流光谱仪
- 批准号:
RTI-2023-00131 - 财政年份:2022
- 资助金额:
$ 5.39万 - 项目类别:
Research Tools and Instruments
Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
- 批准号:
RGPIN-2017-04458 - 财政年份:2022
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
- 批准号:
RGPIN-2017-04458 - 财政年份:2021
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
- 批准号:
RGPIN-2017-04458 - 财政年份:2020
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
- 批准号:
RGPIN-2017-04458 - 财政年份:2019
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
- 批准号:
RGPIN-2017-04458 - 财政年份:2017
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Rheology Facility for Materials Characterization and Tissue Engineering
用于材料表征和组织工程的流变学设施
- 批准号:
RTI-2017-00196 - 财政年份:2016
- 资助金额:
$ 5.39万 - 项目类别:
Research Tools and Instruments
Dynamics of Small Molecules in Supramolecular Systems
超分子系统中小分子的动力学
- 批准号:
121389-2012 - 财政年份:2015
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Dynamics of Small Molecules in Supramolecular Systems
超分子系统中小分子的动力学
- 批准号:
121389-2012 - 财政年份:2014
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Dynamics of Small Molecules in Supramolecular Systems
超分子系统中小分子的动力学
- 批准号:
121389-2012 - 财政年份:2013
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
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Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
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- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
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RGPIN-2017-04458 - 财政年份:2021
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
- 批准号:
RGPIN-2017-04458 - 财政年份:2020
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Supramolecular Dynamics in Solution and in Gels
溶液和凝胶中的超分子动力学
- 批准号:
RGPIN-2017-04458 - 财政年份:2019
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual